Researcher’s Profile

Yiping W. Han, PhD

Body: 

I am a tenured professor of microbial sciences with an interdisciplinary appointment at Columbia University Medical Center and the Vagelos College of Physicians & Surgeons. 

Research Statement: 

My research has been consistently funded by the NIH and involves the role of microbes in human health and disease. My research interests include host-pathogen interactions, human microbiome and oral-systemic connections. The human microbiome is a vast population of microbes that play an essential role in health and disease. Work in our laboratory is focused on the following aspects: (i) investigating the role of oral bacteria in extra-oral infection and inflammation; (ii) investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and gastrointestinal cancers; and (iii) developing genetic tools for mutant construction in bacteria.

Publications: 

Rubinstein, M.R., Baik, J.E., Lagana, S.M., Han, R.P., Raab, W.J., Sahoo, D., Dalerba, P., Wang, T.C. and Han, Y.W. (2019) Fusobacterium nucleatum promotes colorectal cancer through induction of novel Wnt/b-catenin modulator Annexin A1 in proliferating cancerous cells. EMBO Reports doi.org/10.15252/embo.201847638.1. PMID:30833345

Garcia-So, J., Zhang, X., Yang, X., Rubinstein, M.R., Mao, D.Y., Kitajewski, J, Liu, K. and Han, Y.W. (2019) Omega-3 fatty acids suppress Fusobacterium nucleatum-induced placental inflammation originating from maternal endothelial cells. JCI Insight 4: e125436. doi.org/10.1172/jci.insight.125436. PMID: 30728337

Vander Haar, E.L., So, J., Gyamfi-Bannerman, C. and Han, Y.W. (2018) Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence. Anaerobe 50: 55-59. PMID: 29409815