Laboratories
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The Abate-Shen Lab is interested in understanding how basic cellular mechanisms become coopted in cancer and in harnessing these insights to improve cancer diagnosis and treatment.
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The Acharyya Lab studies what makes metastasis lethal and how we can successfully target metastases to improve outcomes for cancer patients.
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We build physically inspired machine learning models of biomolecules and their interactions that are sufficiently performant for systems phenomena to emerge from molecular interactions.
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The Amengual Lab’s research goals are focused on developing targeted therapies for the treatment of lymphoma.
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The Arpaia Lab researches how mucosal immune responses are coordinated to maintain homeostasis and respond to microbial infection, barrier disruption, or alterations in commensal microbial diversity.
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The Axel Lab's research is primarily concerned with olfaction, or the sense of smell. The olfactory system provides an excellent system with which to address basic issues of neuroscience.
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The Azizi Lab develops machine learning, artificial intelligence (AI), and statistical frameworks to uncover how tumors evolve, resist therapies, and evade the immune system.
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The Bartolini lab studies how microtubule dynamics and tubulin modifications regulate synaptic function, neurodegeneration, and tumor biology, with a focus on cytoskeletal signaling in brain cancer.
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The Basu Lab studies the relationship of RNA surveillance and transcription associated DNA mutagenesis in human diseases related to the immune and nervous systems.
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The Califano Lab uses systems biology principles to elucidate and then investigate cell regulatory networks.
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The Chan lab investigates the molecular mechanisms that promote the oncogenesis and survival of cancer cells, with a focus on functional genomics and gastrointestinal cancers.
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We develop regenerative therapies using patient-derived stem cells, biomaterials, and targeted nanoparticles, integrating bioengineering strategies to enhance tissue repair in disease models.
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The Chio Lab uses 3D organoid cultures and genetically engineered mouse models to study redox dependencies in pancreatic cancer.
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The Ciccia Lab investigates how genome instability causes cancer and other genetic disorders.
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The Concepcion lab studies how chromatin deregulation impacts tumor evolution with a focus on lung cancer.
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The Cornish lab develops and translates yeast communities with sense-respond and other higher order functions with the goal is developing next generation therapies.
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The Correa lab engineers nanotechnology and biomaterial platforms to program immune cell behavior and remodel diseased tissues, with a focus on cancer immunotherapy.
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The Crew Lab studies strategies for increasing breast cancer risk assessment and prevention options (e.g., genetic testing, screening, chemoprevention) using health information technology.
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The Cruz-Acuña Lab focuses on integrating aspects of biomaterial engineering, cell and molecular biology, and 3D organoid biology to create engineered 3D organoid platforms
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The Dalla-Favera laboratory uses functional and structural genomic approaches toward the identification of the genetic lesions leading to the transformation of B lymphocytes.
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The Danino Lab focuses on using synthetic biology to program bacteria as a cancer therapy. We also study the design principles of gene circuits to develop novel health and environmental applications.
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The Ding Lab We investigates the molecular and cellular mechanisms that regulate stem cell function in the hematopoietic system.
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The Doulatov lab studies the biology of hematopoietic stem cells (HSCs) and how acquisition of oncogenic mutations transforms HSCs into myeloid malignancies, including MDS and AML.
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The Farber Lab's research is focused on defining how the immune system responds to pathogens and maintains homeostasis with age.
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The Floratos Lab develops collaborative bioinformatics software to support the analysis and visualization of genomic data from a wide range of domains.
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The CURE Lab integrates clinical outcomes data, multi-omics, and novel 3D culture model systems to develop translational tools to study and treat disorders of the upper GI tract
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The Gallitto lab seeks to change how pediatric brain cancer patients are treated using a novel drug discovery and delivery pipeline with computational biology and novel biomedical techniques.
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The Gaublomme lab creates and applies technologies to study biological cells and the biomolecular interactions that drive their intra- and intercellular signaling.
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The Ghosh Lab has a long-standing interest in understanding and elucidating the complexities of transcriptional regulation, with a particular focus on the innate and adaptive immune system.
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The Gill lab studies how brain tumors disrupt neural circuits and how these changes drive seizures, neurological dysfunction, and tumor progression.
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The central effort of the Goff Lab has been a detailed genetic analysis of the replication cycle of the Moloney murine leukemia virus (M-MuLV) and the human immunodeficiency virus type 1 (HIV-1).
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The Greene Lab uses single-molecule optical microscopy to study fundamental interactions between proteins and nucleic acids.
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The Greenwald Lab studies cell-cell interactions, signal transduction, and cell fate specification during C. elegans development, with a focus on LIN-12/Notch.
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The focus of the Gu Lab is to understand molecular mechanisms underlying p53 stabilization and activation in tumor suppression.
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The Gundersen Lab conducts research to understand the role of cytoskeletal elements, termed microtubules, in cell functions such as division, migration and polarity.
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Work in the Han lab focuses on investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and colorectal cancer.
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The Honig Lab's work includes theoretical research, biophysical measurements, the development of software tools, and specific applications to problems of biological importance.
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The goal of the Hur Research Group is to utilize advanced quantitative methods and techniques to spur cancer care innovation and to provide comprehensive evaluation of new technologies or therapies.
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The Izar Lab aims to dissect interactions of cancer and immunity in the tumor development, metastasis and drug resistance using high-dimensional functional single-cell genomics and imaging.
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The Jia Lab uses system biology approaches combined with traditional genetic and biochemical analyses to study the role of epigenetic mechanisms in regulating the functions of the genome.
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The Kam Lab studies T cell activation, an important step in shaping the immune response that is normally carried out by contact-mediated ommunication with an antigen presenting cell (APC).
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The Kaufman Lab investigates single and collective cancer cell invasion in biopolymer gels of specific biochemistry, mechanical properties, and network structure.
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The Kim Lab focuses on elucidating how vascular dynamics regulate disease progression and treatment resistance, with a particular emphasis on translational research.
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The Ultrasound Elasticity and Imaging Laboratory works on developing novel, ultrasound-based techniques for both imaging and therapeutic applications.
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Dr. Kousteni’s research focuses on the role of the bone marrow microenvironment and genomic alterations in the pathogenesis of hematological malignancies.
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The Lentzsch Lab focuses on the identification of novel targets for the treatment of Multiple Myeloma, Multiple Myeloma bone disease and AL amyloidosis.
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The Liu lab studies epigenetics, a biochemcial and biophysical mechanism enabling our genome to integrate a variety of signals by orchestrating gene expression.
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The Lu Lab is interested in understanding basic mechanisms governing chromatin organization and access during normal and cancer development.
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The Mace lab studies the cell biological mechanisms underlying human immune cell migration and cell cycle dynamics in complex microenvironments.
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The Mahat lab studies enhancer-mediated gene misregulation in immune dysfunction diseases to discover and characterize therapeutically relevant enhancers for precision genomic medicine.
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The Manley Lab studies aspects of gene expression, principally in human cells, including transcription of mRNA encoding genes, and splicing and polyadenylation of the resultant mRNA precursors.
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Mendelsohn Lab focuses on understanding normal and abnormal biology of the urothelium, a water-tight epithelial barrier lining the urinary outflow tract that protects against infection.
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The Min lab studies alternative lengthening of telomeres (ALT), a telomerase-independent maintenance pathway, to define mechanisms, biomarkers, and therapeutic targets in ALT-dependent cancers.
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The Mor lab's research seeks to improve treatment outcomes for cancer patients, studying adaptive immune responses to tumors, as well as mechanisms to promote loss of tolerance.
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The Olive Lab focuses on translational research and pancreatic cancer. We are working to facilitate the clinical realization of basic science principles in order to improve the treatment of patients.
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The Palomero lab studies how RHOA G17V (often with TET2 loss) disrupts signaling to drive peripheral T-cell lymphoma and AITL.
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The Passegue Lab studies how hematopoietic stem cells (HSC) regulate blood production during the lifetime of an ever-changing organism.
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Ongoing studies of the Pon Lab focus on the mechanisms for mitochondrial quality control.
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The Prives Lab aims to understand the structure and function of the normal p53 protein and how it differs from the mutant p53 proteins that are commonly found in cancer patients' tumors.
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The Que Lab focuses on the molecular and cellular mechanisms controlling the proliferation and differentiation of stem cells in the esophagus and lung.
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The Rabadan Lab is an interdisciplinary team interested in developing mathematical and computational tools to extract useful biological information from large data sets.
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The Reilly Lab is dedicated to translational and genomic studies of human cardiometabolic disorders.
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The Reshef lab investigates immune responses after bone marrow transplantation and cell therapy and aims to develop novel therapeutic approaches that improve the outcome of cancer immunotherapies.
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The Reya Lab is broadly interested in understanding how stem cell signals are hijacked to drive cancer progression and therapy resistance with a focus on leukemias and pancreatic cancer.
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By using budding yeast as an experimental organism, the Rothstein Lab is able to study essential biological processes such as the mechanisms underlying the recognition and repair of DNA damage.
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The Rustgi laboratory explore cell-type and tissue-type specific actions of certain oncogenes and tumor suppressor genes in modulating the initiation, progression and invasion of GI cancers
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The Schvartzman Lab is interested in understanding how extra- and intra-cellular metabolism regulates chromatin biology.
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The Schwabe Lab utilizes state-of-the-art molecular biology and cutting-edge bioinformatics to better understand liver cancer, liver fibrosis, and non-alcoholic liver disease.
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The Shah Lab uses chemical and biological approaches to study allostery, protein-protein interactions, and mutational effects in signaling proteins, with a focus on tyrosine kinases and phosphatases.
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The Shen Lab investigates the molecular mechanisms of mammalian development and cancer using in vivo analyses of genetically-engineered mouse models.
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The Sims Lab develops new tools for single cell and cell type-specific analysis, focusing mainly on transcriptional and translational regulation.
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The Snoeck Lab focuses on stem cells, ranging from basic stem cell biology to translational research and disease modeling.
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The Spina Lab investigates how radiation reshapes tumor and systemic immunity through preclinical, translational, and clinical research.
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The Stockwell lab sits at the interface of chemistry and biology and is systematically using small molecules to discover mechanisms underlying cellular processes.
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The Symington Lab uses the yeast Saccharomyces cerevisiae as a model eukaryotic system to study the mechanisms and regulation of recombination.
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The Tabas Lab studies the cellular biology of cardiometabolic disease, with an emphasis on molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and NASH in obesity.
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The main focus of the Tavazoie Lab is to understand how cells adapt to changes in their external environment.
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The goal of the Taylor Lab is to understand the role of aneuploidy, whole chromosome or chromosome arm imbalance, in the development of cancer.
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The Thawani lab studies how the mobile genetic elements spread within the eukaryotic host genomes.
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The Viny lab studies epigenetic regulation and 3D chromatin structure during normal blood formation and in blood cancers.
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The Vitkup Lab is working on important biological and biomedical questions. To address scientific challenges, we develop/apply novel computational, theoretical and experimental tools and approaches.
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The Vunjak-Novakovic Lab is focused on tissue engineering approaches to improving human health.
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The Wang Lab applies synthetic and systems biology approaches to design and build new microbes with novel capabilities, leveraging both engineering and evolutionary principles.
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The Wang lab studies the molecular mechanisms governing cell identity and plasticity, focusing on epigenetic and RNA-based regulation of pluripotency and germ cell development.
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The Wang Lab studies how dysregulation of RNA splicing and modifications drives the development and progression of B cell malignancies, with a focus on chronic lymphocytic leukemia (CLL).
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The Wang lab investigates the molecular mechanisms of gastrointestinal carcinogenesis and the role of inflammation in modulating stem cells and promoting gastrointestinal neoplasia using mouse models.
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The Wechsler-Reya Lab studies the signals that control cell growth and differentiation in the nervous system and how these signals are dysregulated in brain tumors.
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The Williams lab harnesses protein engineering, synthetic biology, and immunoengineering to study and manipulate protein-carbohydrate interactions for therapeutic and biomedical applications.
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The Woappi lab investigates how varied cells synchronize their activities to restore damaged tissue.
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We use integrated experimental and computational approaches to investigate the principles of how genetic information is coded and decoded and how to target these processes in cancer and other diseases
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The Yang Lab studies cell-cycle regulation and its dysregulation in cancer to identify vulnerabilities and therapeutic targets, and to improve cancer diagnosis and treatment.
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The Zaccara lab is dedicated to investigating the fundamental mechanisms that regulate mRNA fate in both normal and disease states, with a specific focus on understanding the role of RNA modifications
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The Zha Lab focuses on fundamental mechanisms by which cells respond to DNA damage, and how these responses impact normal lymphocyte development, lymphomagenesis and cancer therapy.
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The Zhang Lab's two major research interests and goals in our laboratory: epigenetic inheritance and cancer epigenetics.
