Physician’s Profile

1

Timothy Cragin Wang, MD

Department of Medicine
Division of Digestive & Liver Diseases
Chief, Division of Digestive and Liver Diseases
Co-leader of the Tumor Biology and Microenvironment Program, Herbert Irving Comprehensive Cancer Center
Introduction:

Dr. Timothy Wang is a leading expert in gastroenterology cancer research and patient care. His research specifically focuses on transgenic/ knockout mice, stem cells, lineage tracing, bone marrow-derived cells, and FACS analysis of immune/epithelial cells in the gut. His laboratory has for decades investigated the molecular mechanisms of gastrointestinal carcinogenesis, and has been continuously funded by the NIH for 29 years and by the NCI for 14 years. His lab has worked for many years on the role of inflammation in promoting gastrointestinal neoplasia, including colon cancer. His research has defined key roles for stromal cells in tumor development, including myeloid cells.

Dr. Wang is the GI Division Chief at Columbia and serves as Co-leader of the Tumor Biology and Microenvironment Program of the Herbert Irving Comprehensive Cancer Center. He also serves as director of the Columbia University NCI U54 Tumor Microenvironment (TMEN) program and directs the Barrett’s Esophageal Translational Research Network (BETRNet) program and the Intestinal Stem Cell Consortium (ISCC) at Columbia.

In addition to his leadership at Columbia, Dr. Wang has served as President of the American Gastroenterology Association (AGA). His work has been recognized with numerous awards, including the Outstanding Investigator Award from the NCI, the Irene and Arthur Fishberg Prize for medical research, the Ruth Leff Siegel Award for pancreatic cancer research, and the William Beaumont Prize in Gastroenterology from the AGA. Over his career, he has organized numerous conferences, including conferences on Gastrin, Regulatory Peptides, AACR Symposium on Gastric Cancer, Tumor Microenvironment, and Keystone Conferences.

Board Certificates
Gastroenterology
Internal Medicine
Areas of Expertise:
  • Cancer Care
  • Colon Cancer Screening and Prevention
  • Gastric Cancer
  • Gastroenterology
  • Internal Medicine
  • Peptic Ulcer Disease
Honors & Awards:

AGA Funderberg Gastric Cancer Award

Publications:

Chang W, Wang H, Kim W, Liu Y, Deng H, Liu H, Jiang Z, Niu Z, Sheng W, Nápoles OC, Sun Y, Xu J, Sepulveda A, Hayakawa Y, Bass AJ, Wang TC. Hormonal suppression of stem cells inhibits symmetric cell division and gastric tumorigenesis. Cell Stem Cell. 2020 Feb 20. pii: S1934-5909(20)30020-5. doi: 10.1016/j.stem.2020.01.020. [Epub ahead of print] PMID: 32142681

Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC. B2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer. Cancer Cell. 2018; 33(1):75-90.e7. doi: 10.1016/j.ccell.2017.11.007. PMID:29249692

Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin1 identifies a skeletal cell with bone, cartilage, and reticular stromal potential. Cell. 2015; 160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042. PMID:5594183

Wang TC, Cardiff RD, Zuckerberg L, Lees E, Arnold A, and Schmidt EV. (1994) Mammary hyperplasia and carcinoma in MMTV-Cyclin D1 transgenic mice. Nature 369:669-71

Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, and Anderson CN. (2000) Concurrent enteric helminth infection modulates inflammation, gastric immune responses, and reduces Helicobacter-induced gastric atrophy. Nature Medicine 6:536-42