Xuebing Wu, PhD

  • Assistant Professor of Medical Sciences (in Medicine and in Systems Biology) (in the Institute for Clinical and Translational Research)

On the web

Profile Headshot

Profile Navigation

Overview

Xuebing Wu, PhD is an Assistant Professor in the Department of Medicine and the Department of Systems Biology at Columbia University Irving Medical Center. Dr. Wu received a BS and MS in Control Science and Engineering from Tsinghua University, Beijing and a PhD in Computational and Systems Biology from MIT. Following his PhD training with Professors Phillip Sharp and Christopher Burge and postdoctoral training with Professor David Bartel, Dr. Wu started his own lab at Columbia in November 2018. Dr. Wu has received a number of distinctions including The RNA Society/Scaringe Young Scientist Award, Pew-Stewart Scholars Award, and NIH Director’s New Innovator Award.

Academic Appointments

  • Assistant Professor of Medical Sciences (in Medicine and in Systems Biology) (in the Institute for Clinical and Translational Research)

Credentials & Experience

Education & Training

  • BS, 2007 Control Science and Engineering, Tsinghua University, China
  • MS, 2009 Control Science and Engineering/Bioinformatics, Tsinghua University, China
  • PhD, 2014 Computational and Systems Biology, Massachusetts Institute of Technology (MIT)
  • Fellowship: 2018 Whitehead Institute / MIT / HHMI, Cambridge, MA

Honors & Awards

  • 2021: Paul A. Marks Scholar, Columbia University
  • 2021: Pershing Square Sohn Prize for Young Investigators in Cancer Research
  • 2020: NIH Director’s New Innovator Award (DP2)
  • 2020: Pew-Stewart Scholars for Cancer Research
  • 2019: The RNA Society / Scaringe Young Scientist Award
  • 2019: Highly Cited Researcher, Clarivate / Web of Science
  • 2018: Finalist, The Regeneron Prize for Creative Innovation in a Postdoc
  • 2017: Margaret and Herman Sokol Postdoctoral Award, Whitehead Institute
  • 2017: Oral Presenter Award, RNA Symposium, University at Albany, SUNY
  • 2016 - 2019: Helen Hay Whitney Postdoctoral Fellowship, Helen Hay Whitney Foundation
  • 2014: Honorable Mention, The Regeneron Prize for Creative Innovation in a Graduate Student
  • 2011 - 2014: International Student Research Fellow, Howard Hughes Medical Institute
  • 2009: Rising Stars of Research, Tsinghua University, China
  • 2008: Top–grade Scholarship (the highest honor), Tsinghua University, China

Research

We study post-transcriptional gene regulation in human health and disease by using integrated experimental and computational approaches.

The Wu laboratory studies fundamental principles of how genetic information is coded, decoded, and evolve, focusing on mammalian systems with an RNA-centric perspective. The Wu lab is also developing high-throughput genomic assays and CRISPR technologies to bridge the discovery of gene regulation with therapeutic development for human diseases, including heart diseases, aging, neurodegeneration, and cancer.

Research Interests

  • Aging
  • Cancer
  • CRISPR Gene Editing
  • Heart Disease
  • Machine Learning (ML)
  • Messenger RNA (mRNA)
  • Neurodegeneration
  • Non-coding RNAs (ncRNAs)
  • Protein Quality Control

Selected Publications

  1. Sikandar Azam*, Feiyue Yang*, Xuebing Wu, Finding functional microproteins. Trends in Genetics, 2024, in press
  2. Jordan Kesner, Xuebing Wu. Mechanisms suppressing noncoding translation. Trends in Cell Biology, 2024, advanced online publication
  3. Peiguo Shi, Xuebing Wu, Programmable RNA targeting with CRISPR-Cas13. RNA Biology, 2024, 21:1–9
  4. Jordan S Kesner*, Ziheng Chen*, Peiguo Shi, Alexis O Aparicio, Michael R. Murphy, Yang Guo, Aditi Trehan, Jessica E. Lipponen, Yocelyn Recinos, Natura Myeku, Xuebing Wu. Noncoding translation mitigation. Nature, 2023, 617:395–402
  5. Xuebing Wu, David P. Bartel. Widespread influence of 3′-end structures on mammalian mRNA processing and stability. Cell, 2017, 169: 905–917
  6. Xuebing Wu^, David P. Bartel^ (^co-corresponding author), kpLogo: positional k-mer analysis reveals hidden specificity in biological sequences. Nucleic Acids Research, gkx323
  7. Xuebing Wu, David A. Scott, Andrea J. Kriz, Anthony C. Chiu, Patrick D. Hsu, Daniel B. Dadon, Albert W. Cheng, Alexandro E. Trevino, Silvana Konermann, Sidi Chen, Rudolf Jaenisch, Feng Zhang, Phillip A. Sharp. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nature Biotechnology, 2014, 32:670-676
  8. Xuebing Wu, Phillip A. Sharp. Divergent transcription: a driving force for new gene origination? Cell, 2013, 155:990-996
  9. Albert E. Almada*, Xuebing Wu*, Andrea J. Kriz, Christopher B. Burge, Phillip A. Sharp (*equal contribution). Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature, 2013, 499:360–363

For a complete list of publications, please visit PubMed.gov