Jose McFaline-Figueroa, PhD

  • Assistant Professor of Biomedical Engineering

Overview

José L. McFaline-Figueroa is an Assistant Professor of Biomedical Engineering in the Department of Biomedical Engineering at Columbia University Irving Medical Center (CUIMC). Dr. McFaline-Figueroa's research aims to define the molecular changes that cancer cells undergo in response to therapy and the genetic requirements of that response. The goal of his laboratory is to leverage this information to arrive at new treatment strategies for tumor types that frequently fail standard-of-care. He received his B.S. from the University of Puerto Rico at Mayagüez, his PhD from the Massachusetts Institute of Technology and performed his post-doctoral work at the University of Washington.

Academic Appointments

  • Assistant Professor of Biomedical Engineering

Gender

  • Male

Credentials & Experience

Education & Training

  • PhD, Cancer Cell Biology, Massachusetts Institute of Technology
  • BS, University of Puerto Rico at Mayagüez

Committees, Societies, Councils

  • American Society of Human Genetics
  • Biomedical Engineering Society (Cellular and Molecular Bioengineering group)

Honors & Awards

  • Allen Institute Distinguished Investigator Award, September 2023
  • HICCC Emerging Leaders Program, September 2023
  • Office of the Provost Grant for Junior Faculty who Contribute to the
    Diversity Goals of the University, Columbia University, July 2022
  • NSF CAREER Award, February 2022
  • NIH NHGRI Genomic Innovator Award, August 2021
  • Emerging Scholar in Genome Sciences, Center for Public Health Genomics at
    the University of Virginia. September 2020

Research

Dr. McFaline-Figueroa's laboratory is interested in defining the molecular changes that cells and tissues undergo in response to different therapies and how that landscape depends on genetic background. Their goal is to leverage these atlases of cellular response to arrive at strategies to treat human disease, with a particular focus on cancer.

Research Interests: Cancer Genomics, Single-cell Genomics, Chemical Genomics, Multiplex gene editing, High-throughput Molecular Screens

Selected Publications

  1. McFaline-Figueroa, J.L., Srivatsan, S., Hill, A.J., Gasperini, M., Jackson, D.L., Saunders, L., Domcke, S., Regalado, S.G., Lazarchuck, P., Alvarez, S., Monnatt Jr, R.J., Shendure, J., Trapnell, C. # 2024. Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. Cell Genomics, 100487. doi: 10.1016/j.xgen.2023.100487.
  2. McFaline-Figueroa, J.L., Srivatsan, S., Hill, A.J., Jackson, S.L., Saunders, L., Domcke, S., Regalado, S.G., Lazarchuck, P., Álvarez, S., Monnat, R.J., Shendure, J., #Trapnell C. 2023. Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy. bioRxiv. doi: 10.1101/2023.03.10.531983.
  3. Srivatsan, S.*, McFaline-Figueroa, J.L.*, Ramani, V.*, Saunders, L., Cao, J., Packer, J., Pliner, H.A., Jackson, D., Daza, R., Christiansen, L., Zhang, F., Steemers, F., Shendure, J. and Trapnell, C. 2020. Massively multiplex chemical transcriptomics at single cell resolution. Science, 367(6473), p.45-51. doi: 10.1126/science.aax6234.