Riccardo Dalla-Favera, MD
- Percy and Joanne Uris Professor of Clinical Medicine
- Professor of Pathology and Cell Biology, Genetics and Development and Microbiology and Immunology (in the Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center)
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Overview
Academic Appointments
- Percy and Joanne Uris Professor of Clinical Medicine
- Professor of Pathology and Cell Biology, Genetics and Development and Microbiology and Immunology (in the Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center)
Administrative Titles
- Director, Institute for Cancer Genetics
Research
The research program in the Dalla-Favera laboratory is aimed at the identification of the molecular pathogenesis of human B cell malignancies. Functional and structural genomic approaches are used toward the identification of the genetic lesions leading to the transformation of B lymphocytes. The genomic landscape of the tumors is then recapitulated in genetically modified mice in order to construct models for pre-clinical testing of science-based new therapeutic modalities.
Selected Publications
- Super-enhancer hypermutation alters oncogene expression in B cell lymphoma
Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L, Dalla-Favera R.
Nature. 2022
PMID: 35794478 - Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis
Corinaldesi C, Holmes AB, Shen Q, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K.
Front Immunol. 2022
PMID: 35095922 - Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma
Fangazio M, Ladewig E, Gomez K, Garcia-Ibanez L, Kumar R, Teruya-Feldstein J, Rossi D, Filip I, Pan-Hammarström Q, Inghirami G, Boldorini R, Ott G, Staiger AM, Chapuy B, Gaidano G, Bhagat G, Basso K, Rabadan R, Pasqualucci L, Dalla-Favera R.
Proc Natl Acad Sci U S A. 2021
PMID: 34050029 - Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome
Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K
J Exp Med. 2020.
PMID: 32603407 - Chronic lymphocytic leukaemia: from genetics to treatment
Bosch F, Dalla-Favera R
Nat Rev Clin Oncol. 2019.
PMID: 31278397 - Repurposing dasatinib for diffuse large B cell lymphoma
Scuoppo C, Wang J, Persaud M, Mittan SK, Basso K, Pasqualucci L, Rabadan R, Inghirami G, Grandori C, Bosch F, Dalla-Favera R
Proc Natl Acad Sci USA. 2019.
PMID: 31383760 - MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis
Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R
Cancer Cell. 2018.
PMID: 30205047 - Genetics of diffuse large B-cell lymphoma
Pasqualucci L, Dalla-Favera R
Blood. 2018.
PMID: 29666115, DOI: 10.1182/blood-2017-11-764332
The molecular pathogenesis of chronic lymphocytic leukaemia
Fabbri G, Dalla-Favera R
Nat Rev Cancer. 2016.
PMID: 26911189 - Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L
Nat Med. 2015.
PMID: 26366712 - Germinal centres and B cell lymphomagenesis
Basso K, Dalla-Favera R
Nat Rev Immunol. 2015.
PMID: 25712152 - MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma
Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R
Nat Immunol. 2013.
PMID: 23974956 - Combined genetic inactivation of β2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R
Cancer Cell. 2011.
PMID: 22137796 - Analysis of the coding genome of diffuse large B-cell lymphoma
Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R
Nat Genet. 2011.
PMID: 21804550 - Inactivating mutations of acetyltransferase genes in B-cell lymphoma
Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R
Nature. 2011.
PMID: 21390126 - BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L, Dalla-Favera R
Cancer Cell. 2010.
PMID: 21156281 - Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
Ye BH, Lista F, Lo Coco F, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R
Science. 1993.
PMID: 8235596 - Identification of reciprocal translocation sites within the c-myc oncogene and immunoglobulin mu locus in a Burkitt lymphoma
Gelmann EP, Psallidopoulos MC, Papas TS, Dalla-Favera R
Nature. 1983.
PMID: 6419123
For a complete list of publications, please visit PubMed.gov