Researcher’s Profile

Jianwen Que, MD, PhD

Research Statement: 

I am an Associate Professor of Medicine at Columbia University. My research is focused on the role of stem/progenitor cells in homeostasis and disease pathogenesis in gastrointestinal organs including esophagus, stomach etc. I have made several different knockin overexpression and knockout mouse lines, so my lab has expertise in mouse genetic modeling and in the isolation, immunostaining of cells and tissues, and related techniques. We also have major expertise in the areas of stem cell differentiation, isolation and culture of stem cells, stem cell/microenvironment interaction in the initiation and progression of esophageal diseases including eosinophilic esophagitis and Barret’s esophagus. Part of our findings were published in journals including Nature, Cell Stem Cell, Developmental Cell and Journal of Clinical Investigation. My training in clinical medicine has helped shape my research direction, that is, to model and find cures for clinical diseases. The long-term interests in my laboratory are focused on understanding the molecular processes that collectively serve to regulate the morphogenesis and maintenance of two foregut-derived organs, the lung and esophagus. Currently, we focus on three diseases, Eosinophilic esophagitis, Barrett’s esophagus and lung fibrosis.

Publications: 

Kim E, Jiang M, Huang H, Zhang Y, Tjota N, Gao X, Robert J, Gilmore N, Gan L, Que J. Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation. Dev Cell. 2019; 51(6):675-683. PMID: 31813798

Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 4;23(4):516-529 PMID: 30244870

Jiang M, Li H, Zhang Y, Yang Y, Lu R, Liu K, Lin S, Lan X, Wang H, Wu H, Zhu J, Zhou Z, Xu J, Lee DK, Zhang L, Lee YC, Yuan J, Abrams JA, Wang TC, Sepulveda AR, Wu Q, Chen H, Sun X, She J, Chen X, Que J. Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus. Nature. 2017; 550(7677):529-533. PMID: 29019984