Hee Won Yang, PhD
Our lab focuses on understanding the signaling processes that underlie the decision to proliferate. Although many proteins regulating proliferation have been identified, it is still unclear how these central components are wired into circuits to carry out the decision of proliferation. In particular analysis of signaling dynamics in space and time and tools to probe interactions between components have been missing. To address these questions, we apply an automated imaging system and live-cell biosensors to monitor signaling processes at the single-cell level. We classify heterogeneous population and further explore underlying molecular mechanism. We are currently studying the decision of proliferation in normal condition and pathological condition, cancer.
HW Yang#, M Chung, T Kudo, and T Meyer#. Competing memories of mitogen and p53 signaling control cell-cycle entry. Nature, 549: 404-408, 2017 (Cover article)
HW Yang*#, SR Collins*#, and T Meyer#. Locally excitable Cdc42 signals steer cells during chemotaxis. Nat Cell Biol, 18: 191-201, 2016
SR Collins, HW Yang, KM Bonger, EG Guignet, TJ Wandless, and T Meyer. Using light to shape chemical gradients for parallel and automated analysis of chemotaxis. Mol Sys Biol, 11(4): 804, 2015
HW Yang, MK Shin, S Lee, J Kim, WS Park, K Cho, T Meyer, and WD Heo. Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell, 47: 281-290, 2012
J Won*, HW Yang*, SY Shin*, JH Lee, WD Heo, and K Cho. The cross regulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor. J Mol Cell Biol, 4: 153-163, 2012 (Cover article)