Physician’s Profile

Eileen P. Connolly, MD, PhD

Department of Radiation Oncology

Eileen Connolly, M.D., Ph.D. is Assistant Professor of Radiation Oncology at New York Presbyterian/Columbia University Medical Center. She is a board-certified radiation oncologist who cares for patients with all types of cancer but specializes in the treatment of breast and pediatric malignancies with radiation therapy. Dr. Connolly has published various articles in her field, including several related to breast cancer. In addition to her breast research she participates in a number of Children’s Oncology Group (COG) protocols for the treatment of pediatric malignancies and works closely with the Pediatric Oncology group at Morgan Stanley Children's Hospital of New York-Presbyterian/Columbia University Medical Center.

Dr. Connolly received her M.D./Ph.D. degree, internal medicine and radiation oncology training at New York University School of Medicine, where she was Chief Resident of Radiation Oncology. During her residency training she received both the 2010 Varian Medical Systems/RSNA Research Resident Grant and the 2010 ASTRO Residents/Fellows in Radiation Oncology Award. In addition, Dr. Connolly was trained in Gamma Knife Radiosurgery at the University of Pittsburgh Medical Center - Center for Image-Guided Neurosurgery, pioneers in the field of stereotactic radiosurgery for brain cancers and malformations.

Besides her clinical duties Dr. Connolly is the director of a translational research laboratory in the Center for Radiological Research (CRR) in which she pursues her research interests in understanding the mechanisms of radiation resistance of cancer. Specifically her work focuses on the PI3K/Akt pathway with a goal of developing targeted agents that may be used as radiation sensitizers to reduce the risk of local recurrence. For her research she has received the 2012 Radiological Society of North America (RSNA) Research Seed grant, and a 2012 Irving Institute/Clinical Trials Office Pilot Award.

Board Certificates
Radiation Oncology
Areas of Expertise:
  • Thyroid Cancer
  • Breast Cancer
  • Radiation Oncology
  • Pediatric Cancer

Horowitz DP, Wang TJ, Wuu CS, Feng W, Drassinower D, Lasala A, Pieniazek R, Cheng S, Connolly E, Lassman AB. Fetal radiation monitoring and dose minimization during intensity modulated radiation therapy for glioblastoma in pregnancy. J Neurooncol. 2014 Nov;120(2):405-9. doi: 10.1007/s11060-014-1565-4. PMID:25096798

Min, C., Connolly E, Chen, T., Jozsef, G., and Formenti, S.C. Hypo-fractionated Radiation Therapy for Early Stage Breast Cancer: Outcomes, Toxicities, and Cost Analysis. Breast J. 2014 May-Jun;20(3):267-73.

Connolly E, Mathew, M., Tam, M., King, J.V., Kunnakkat, S.D., Parker, E.C., Golfinos, J.G., Gruber, M.L., and Narayana, A. Involved Field Radiation Therapy after Surgical Resection of Solitary Brain Metastases - Mature Results. Neuro-Oncology. Neuro Oncol. 2013 May;15(5):589-94.

Horowitz, D.P., Sharma, C.S., Connolly E, Gidea-Addeo,D., and Deutsch, I. Secretory carcinoma of the breast: Results from the survival, epidemiology and end results database. The Breast 2012 Jun;21(3):350-3.

Connolly E, Braunstein, S., Formenti, S., and Schneider, R.J. Hypoxia inhibits protein synthesis through a 4E-BP1 & elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell. Biol. 2006 May; 26(10):3955-65.

Connolly E, Thuiller, V., Rouy, D., Bouetard, G., and Schneider, R.J. Inhibition of Cap-Initiation complexes linked to a novel mechanism of eIF4G depletion in acute myocardial ischemia. Cell Death and Diff. 2006 Sept;13(9):1586-94.

Ioffe E, Moon B, Connolly E, Friedman JM. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc. Natl. Acad. Sci. USA 1998; 95:11852-7.

Li C, Ioffe E, Fidahusein N, Connolly E, Friedman J.M. Absence of soluble leptin receptor in plasma from dbPas/dbPas and other db/db mice.J Biol Chem. 1998. 273:10078-82.

Hung CF, Holzmacher R, Connolly E, Berenbaum MR, Schuler MA. Conserved promoter elements in the CYP6B gene family suggest common ancestry for cytochrome P450 monooxygenases mediating furanocoumarin detoxification. Proc. Natl. Acad. Sci. USA 1996.93:12200-5.