Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases

This study is being done to answer the following question: Can a type of stereotactic radiosurgery (SRS) radiation treatment called fractionated SRS (or FSRS) completed over 3 treatments to the areas of cancer in your brain delay the time until the cancer worsens or returns compared to the usual SRS given in 1 treatment? We are doing this study because we want to find out if this approach is the same or better than the usual approach for your brain metastasis. The usual approach for patients with cancer that has spread to the brain who are not in a study is treatment with SRS that delivers a high dose of radiation in a single treatment to the small areas of cancer in the brain. This treatment may reduce or stop symptoms for at least a month or longer.

Are you Eligible? (Inclusion Criteria)

• Are you 18 years of age or older? Do you have brain metastases following a diagnosis of non-small cell lung cancer, melanoma, breast cancer, renal cell carcinoma, or gastrointestinal cancer? Are you able to have MRI scans? Are you able to come to the clinic for regularly scheduled treatments and assessments?