A Phase 2, Multicenter, Open-Label Study of DKN-01 in Combination with Tislelizumab ± Chemotherapy as First-Line or Second-Line Therapy in Adult Patients with Inoperable, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction

You are being invited to take part in a research study that includes studying DKN-01 combined with another investigational drug called tislelizumab and your physician’s choice of a combination of drugs generally used to treat your type of cancer, either capecitabine and oxaliplatin (referred to as CAPOX) OR leucovorin calcium, fluorouracil, and oxaliplatin (referred to as mFOLFOX6) in advanced gastric or gastroesophageal junction (GEJ) cancer. DKN-101 works by targeting the DKK1 protein, which is present in high levels in your type of tumor. The purpose of this study is to find out if combining DKN-01 with tislelizumab and CAPOX (capecitabine + oxaliplatin) or mFOLFOX6 (leucovorin calcium + fluorouracil + oxaliplatin) will be safe and if it will delay the chance of your cancer growing or spreading.

Are you Eligible? (Inclusion Criteria)

• You must be 18 years of age or older. -You must have been diagnosed with advanced gastric or gastroesophageal junction (GEJ) cancer. -You must be willing to have the study drug administered through a vein in your arm (intravenously).