A Phase 1/2 Trial of Selinexor and Temozolomide in Recurrent Glioblastoma

This study is being done to answer the following question: How does selinexor given after temozolomide compare to temozolomide alone for lengthening the time that you can live with your brain cancer without it getting worse? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your brain cancer. The usual approach is defined as care most people get for brain cancer.

Are you Eligible? (Inclusion Criteria)

• Are you 18 years of age or older? 2) Have you been diagnosed with glioblastoma, and have previously been treated with temozolomide plus radiotherapy? 3) Are you able to come to the clinic for regularly scheduled treatment and evaluation?