New Clinical Trial Targets High-Fat, Low-Carb Diet and Cancer Drugs

Siddhartha Mukherjee, MD, DPhil, will lead a new clinical trial to study whether a high-fat, low-carbohydrate diet could improve outcomes for patients with lymphoma and endometrial cancer. The new trial, which is initially recruiting 40 patients, is the first in a series of similar interventions being planned at other centres in the U.S. and Europe by members of a new international working group focused on “rethinking human diets for cancer.” Dr. Mukherjee, best known for his Pulitzer prize-winning book, The Emperor of All Maladies: A Biography of Cancer, is associate professor of medicine at Columbia Univeristy Irving Medical Center and a member of the Herbert Irving Comprehensive Cancer Center. As reported by The Guardian, he said, "Physiologically we’re discovering that not every calorie is equal. You could have two different diets, equal in terms of energy, but with two very different effects on the cancer.” 

The patients will be treated with a licensed drug, Aliqopa, that has previously been shown to have limited effects in such patients. However, recent animal studies, including a recent paper in Nature from Mukherjee’s lab, suggest its effectiveness could be significantly boosted when combined with diet changes aimed at lowering insulin levels. For the full article, visit The Guardian.