Physician’s Profile

Top Doctor: 

Mark L. Heaney, MD, PhD

Department of Medicine
Division of Hematology/Oncology

Mark Heaney received his undergraduate education at Harvard and graduate education at the University of Virginia where he received an M.D. and a Ph.D. in microbiology. After Internal Medicine residency at SUNY Stony Brook, he had fellowship training in Hematology and Medical Oncology at Memorial Sloan-Kettering Cancer Center. Dr. Heaney subsequently joined the faculty at Memorial Sloan-Kettering Cancer Center. As a member of the Leukemia Service for nearly 20 years, Dr. Heaney continued laboratory research, initially studying the cell surface receptors that govern white blood cell development and leukemia cell growth. More recently, he has focused on metabolic differences between leukemia cells and normal cells that can provide insight into how leukemias behave in the individual patient and how they respond to treatment. His finding that vitamin C has the potential to blunt the beneficial effects of chemotherapy has been widely cited.

Dr. Heaney has also been an active clinical investigator. He has been the Principal Investigator of many clinical trials that have aimed at developing new treatments for leukemia. In particular, he has focused on new treatments of the myeloproliferative neoplasms, primary myelofibrosis, polycythemia vera and essential thrombocythemia, but has also studied new treatments for chronic myeloid leukemia, mastocytosis and Langerhans cell histiocytosis in keeping with his clinical expertise in rare blood cancers.

Dr. Heaney joined the faculty at CUMC in January, 2013. He has continued his commitment to caring for patients with blood cancers, developing new treatments including cutting edge clinical trials, and laboratory research that concentrates on translating discoveries from the bench to the bedside. He also renewed his investment in medical education, becoming Director of the Hematology and Medical Oncology Fellowship Program in 2014.

Board Certificates
Medical Oncology
Areas of Expertise:
  • Myelodysplastic Syndrome
  • Leukemia
  • Cancer Care
  • Acute Leukemia
  • Acute Lymphocytic Leukemia
  • Acute Myelogenous Leukemia
  • Acute Myeloid Leukemia
  • Aplastic Anemia
  • Chronic Leukemia
  • Chronic Lymphocytic Leukemia
  • Chronic Lymphoid Leukemia
  • Chronic Myelogenous Leukemia
  • Essential Thrombocythemia
  • Hairy Cell Leukemia
  • Hematologic Malignancy
  • Histiocytosis
  • Immune Thombocytopenic Purpura
  • Large Granular Lymphocytic Leukemia
  • Lymphoblastic Leukemia
  • Myelofibrosis
  • Myeloproliferative Disease
  • Polycythemia Vera
  • Waldenstrom's Macroglobulinemia
Honors & Awards:

2014                              Fellow, American College of Physicians

2008                              Abstract Reviewer and Oral Session Chair, ASH Annual Meeting

2002                              Meet the Professor, ACP-ASIM Annual Meeting

2001                              Hematology Fellows Attending Teaching Award, Memorial Sloan-Kettering

1999                              Who’s Who In America

1998-2001                  Translational Research Award, Leukemia and Lymphoma Society

1996-2001                  Catherine and Frederick R. Adler Chair for Junior Faculty

1993-1996                  NIH Physician Scientist Award

1992                              Sloan-Kettering Clinical Scholar, Charles A. Dana Fellow

1990                              American Cancer Society Clinical Fellow


Heaney ML, Vera JC, Raines MA, Golde DW:  Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor a subunits are independently regulated in HL-60 cells.  Proc Natl Acad Sci USA 92:2365-2369, 1995

Heaney ML, Golde DW:  Myelodysplasia.  New Engl J Med 340:1649-1659, 1999

Niu L, Golde DW, Vera JC, Heaney ML:  Kinetic resolution of two mechanisms for high-affinity granulocyte-macrophage colony-stimulating factor binding to its receptor.  Blood  94:3748-3753, 1999

Golde DW, Caggiano J, Heaney ML: Cladribine misdosing in hairy cell leukemia: a cause for apparent response failure.  Leukemia Lymphoma 43: 365-367, 2002

Brown WE, Coakley FV, Heaney ML: CT of renal involvement by Rosai Dorfman Disease.  Abdominal Imaging 27: 214-216, 2002