Researcher’s Profile

Yong-Guang Yang, MD, PhD

Body: 

Dr. Yang is a Professor of Medical Sciences at Columbia University. He received his PhD in Immunology in 1991 from Norman Bethune University of Medical Sciences, China. Dr. Yang spent about one and a half years (1992-1994) as a Visiting Scientist at the Mitsubishi Kagaku Institute of Life Sciences, Japan where he worked on molecular cloning of porcine T-cell receptors. He did his postdoctoral training in Transplantation Immunology in Dr. Megan Sykes’ laboratory in the Transplantation Biology Research Center at the Massachusetts General Hospital/Harvard Medical School in Boston (1994-1997). Dr. Yang then worked as an Instructor, Assistant Professor, and Associate Professor in the Department of Surgery at Massachusetts General Hospital/Harvard Medical School for 13 years, and joined the Faculty at Columbia University and the Columbia Center for Translational Immunology in 2010.

Dr Yang’s research involves allogeneic and xenogeneic transplantation immunology, stem cell transplantation, and humanized mouse models

Research Statement: 

Transplantation Immunology: Graft rejection and tolerance induction; GVHD and GVT effects; Humanized mouse models.

Lab Members: 
Hui Wang, MD, PhD, Associate Research Scientist
Mo Chen, Student
Yang Li, Student
Xiaoyi Hu, Lab Technician
Publications: 

(Selected from >100 papers)

Jin CH, Li Y, Xia J, Li Y, Chen M, Hu Z, Mapara MY, Li W, Yang YG. CXCR4 blockade improves leukemia eradication by allogeneic lymphocyte infusion. Am J Hematol. 2018;93(6):786-793. 2018 Mar 30. doi: 10.1002/ajh.25099. [Epub ahead of print]. NIHMSID 955335

Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond C, Kuriakose G, D’Agati V, Winchester R, Sykes M, Yang YG, Tabas I.  Hypercholesterolemia induces T cell expansion in humanized immune mice. J Clin Invest 2018;128(6):2370–2375. https://doi.org/10.1172/JCI97785.

Zhang M, Dong Y, Hu F, Yang D, Zhao Q, Lv C, Wang Y, Xia C, Weng Q, Liu X, Li C, Zhou P, Wang T, Guan Y, Guo R, Liu L, Geng Y, Wu H, Du J, Hu Z, Xu S, Chen J, He A, Liu B, Wang D, Yang YG, Wang J. Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nature Immunology 2018;19(3):279-290. doi: 10.1038/s41590-018-0046-x. Epub 2018 Feb 12. PMID: 29434353

Wu X, Chen H, Wu C, Wang J, Zhang S, Gao J, Wang H, Sun T, Yang YG. Inhibition of intrinsic coagulation improves safety and tumor-targeted drug delivery of cationic solid lipid nanoparticles. Biomaterials 2018;156:77–87.

Tan S, Li Y, Xia J, Jin CH, Hu Z, Duinkerken G, Li Y, Maharlooei MK, Chavez E, Nauman G, Danzl N, Nakayama M, Roep BO, Sykes M, Yang YG. Type 1 diabetes induction in humanized mice. Proc Natl Acad Sci USA 2017;114:10954-59. PMCID: PMC5642714

Wu H, Zhen Y, Xu ZG, Ma Z, Li H, Yu J, Wang XY, Yi H, Yang YG. Arginase-1-dependent promotion of Th17 differentiation and disease progression by MDSCs in systemic lupus erythematosus. Sci Transl Med. 2016 Mar 23;8(331):331ra40. doi: 10.1126/scitranslmed.aae0482.

Hu Z, Xia J, Fan W, Wargo J, Yang YG. Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice. Oncotarget 2016;7(6):6448-6459. doi: 10.18632/oncotarget.7044. [Epub ahead of print].

Wang H, Yang YG. The complex and central role of interferon-g in graft-versus-host disease and graft-versus-tumor activity. Immunol Rev. 2014 Mar;258(1):30-44. NIHMSID # 579492

Rong Z, Wang M, Hu Z, Stradner M, Zhu S, Kong H, Yi H, Goldrath A, Yang YG, Xu Y, Fu X. An effective approach to prevent immune rejection of human ESC-derived allografts. Cell Stem Cell 2014;2:14(1):121-30. doi: 10.1016/j.stem.2013.11.014. PMCID: PMC4023958.

Hu Z, Yang YG. Full reconstitution of human platelets in humanized mice after macrophage depletion. Blood 2012;120(8):1713-6. Epub 2012 Jul 6. PMCID: PMC3429310.

Yang Y, Wang H, Yu H, Yeap BY, Liang T, Wang G, Cheng T, Yang YG. IFN-g promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation. Blood 2011;118(13):3721-4. Epub 2011 Aug 11. PMCID: PMC3186344.

Hu Z, van Rooijen N, Yang YG. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 2011;118(22):5938-46. Epub 2011 Sep 16. PMCID: PMC3228505.

Wang H, Wu X, Wang Y, Oldenborg PA, Yang YG. CD47 is required for suppression of allograft rejection by donor specific transfusion.  J Immunol. 2010;184:3401-3407. PMCID: PMC3670954

Ide K, Wang H, Liu J, Wang X, Asahara T, Sykes M, Yang YG, Ohdan H. Role for CD47-SIRPa signaling in xenograft rejection by macrophages. Proc Natl Acad Sci USA 2007;104(12):5062-5066. PMCID: PMC1829264

Wang H, Madariaga ML, Wang S, Van Rooijen N, Oldenborg PA, Yang YG.  Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells.  Proc Natl Acad Sci USA 2007;104:13744-13749. PMCID: PMC1949343

Yang YG, Sykes M. Xenotransplantation - Current Status and a Perspective on the Future. Nature Reviews Immunology 2007;7:519-531.

Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg P-A, Sykes M, Yang YG.  Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood 2007;109:836-842. PMCID: PMC1785095

Lan P, Tonomura N, Wang S, Yang YG.  Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation.  Blood 2006;108:487–492.