Physician’s Profile

Serge Cremers, PhD, PharmD

Department of Pathology & Cell Biology
Division of Laboratory Medicine

Serge Cremers was born in 1969 in Heerlen, The Netherlands. He received his PharmD from the University of Groningen in 1996 and his PhD from Leiden University in The Netherlands in 2004. He joined Columbia University in 2006 after working for 2 years as a Clinical Pharmacologist at Novartis Oncology in Florham Park, NJ. He is currently an Associate Professor of Pathology & Cell Biology and Medicine at CUMC, where he is also an attending Clinical Chemist. He is director of Pathology's Clinical Pharmacology and Toxicology Laboratory as well as director of the Biomarkers Core Laboratory of the Irving Institute for Clinical and Translational Research. Dr Cremers' research focuses on clinical and translational pharmacology of drugs in cancer, transplantation, contraception and metabolic bone diseases. He has (co-)authored over 100 original papers and a number or reviews and book chapters. He is also Senior Editor (Reviews) of the British Journal of Clinical Pharmacology.


Areas of Expertise:
  • Pharmacology
  • Clinical Chemistry

A. Original, Peer-reviewed articles:

1. Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, and Abate-Shen C.  Co-clinical analysis of a genetically-engineered mouse model and human prostate cancer reveals significance of NKX3.1 expression for response to 5-alpha-reductase inhibition. Eur Urology 2017; in press.  

2. Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017;168(5):878-889

3. Praditpan P, Hamouie A, Basaraba CN, Nandakumar R, Cremers S, Davis AR, Westhoff CL. Pharmacokinetics of levonorgestrel and ulipristal acetate emergency contraception in women with normal and obese body mass index. Contraception. 2017, In Press.

4. Westhoff CL, Pike MC, Cremers S, Eisenberger A, Thomassen S, Rosing J. Endogenous thrombin potential changes during the first cycle of oral contraceptive use. Contraception. 2017, In Press.

5. Basaraba CN, Westhoff CL, Pike MC, Nandakumar R, Cremers S. Estimating systemic exposure to levonorgestrel from an oral contraceptive. Contraception. 2016, In Press.

6. Amengual JE, Prabhu SA, Lombardo M, Zullo KM, Johannet PM, Gonzalez Y, Scotto L, Jirau-Serrano X, Wei Y, Duong JK, Nandakumar R, Cremers S, Verma A, Elemento O, O'Connor OA. Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug : Drug Combination with Ibrutinib. Clin Cancer Res. 2016, in Press.

7. Carrelli A, Bucovsky M, Horst R, Cremers S, Zhang C, Bessler M, Schrope B, Evanko J, Blanco J, Silverberg SJ, Stein EM. Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women. J Bone Miner Res. 2016, In Press.

8. Cheslack-Postava K, Cremers S, Bao Y, Shen L, Schaefer CA, Brown AS. Maternal serum cytokine levels and risk of bipolar disorder. Brain Behav Immun. 2016, In Press.

9. Greenlee H, Odgen Gaffney A, Aycinena AC, Koch P, Contento I, Karmally W, Richardson JM, Shi Z, Lim E, Tsai WY, Santella RM, Blaner WS, Clugston RD, Cremers S, Pollak S, Sirosh I, Crew KD, Maurer M, Kalinsky K, Hershman DL. Long-term diet and biomarker changes after a short-term intervention among Hispanic breast cancer survivors: The ‘Cocinar Para Su Salud’ randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2016;25(11):1491-1502.

10. Saland JM, Satlin LM, Zalsos-Johnson J, Cremers S, Ginsberg HN. Impaired postprandial lipemic response in chronic kidney disease. Kidney Int. 2016; 90(1):172-80.

11. Rubin MR, Cusano NE, Fan WW, Delgado Y, Zhang C, Costa AG, Cremers S, Dworakowski E, Bilezikian JP. Therapy of Hypoparathyroidism With PTH(1-84): A Prospective Six Year Investigation of Efficacy and Safety. J Clin Endocrinol Metab. 2016;101(7):2742-50.

12. Kancheva Landolt N, Bunupuradah T, Kosalaraksa P, Ubolyam S, Thammajaruk N, Cremers S, Zott R, Kerr S, Ananworanich J; HIV-NAT 176 study. High variability of hormonal levels and no clinically relevant interaction between ethinyl estradiol, desogestrel and lopinavir/ritonavir in a small sample of HIV-positive adolescents. J Acquir Immune Defic Syndr. 2016; 72(5):507-12.

13. Alsahli A, Kiefhaber K, Gold T, Muluke M, Jiang H, Cremers S, Schulze-Späte U. Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation. Calcif Tissue Int. 2016; 98(5):511-9.

14. Morrell KM, Cremers S, Westhoff CL, Davis AR. Relationship between etonogestrel level and BMI in women using the contraceptive implant for more than 1 year. Contraception. 2016; 93(3):263-5.

15. Westhoff CL, Eisenberger A, Tang R, Cremers S, Grossman LV, Pike MC. Clotting factor changes during the first cycle of oral contraceptive use. Contraception. 2016;93(1):70-6.

16. Muluke M, Gold T, Kiefhaber K, Al-Sahli A, Celenti R, Jiang H, Cremers S, Van Dyke T, Schulze-Späte U. Diet-Induced Obesity and Its Differential Impact on Periodontal Bone Loss. J Dent Res. 2016;95(2):223-9.

17. Cohen A, Kamanda-Kosseh M, Recker RR, Lappe JM, Dempster DW, Zhou H, Cremers S, Bucovsky M, Stubby J, Shane E. Bone Density After Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis. J Clin Endocrinol Metab. 2015;100(11):4208-14.

18. Amengual JE, Johannet PM, Lombardo M, Zullo KM, Hoehn D, Bhagat G, Scotto L, Jirau-Serrano X, Radeski D, Heinen J, Jiang H, Cremers S, Zhang Y, Jones SS, O'Connor OA. Dual targeting of protein degradation pathways with the selective HDAC6 inhibitor, ACY-1215, and bortezomib is synergistic in lymphoma. Clin Cancer Res. 2015;21(20):4663-75.

19. Ozcan L, Xu X, Deng SX, Ghorphade DS, Thomas T, Cremers S, Hubbard B, Serrano-Wu MH, Gaestel M, Landry DW, Tabas I. Treatment of Obese Insulin-Resistant Mice with an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.Diabetes. 2015;64(10):3396-405.

20. Zullo KM, Guo Y, Cooke LS, Jirau-Serrano X, Mangone M, Scotto L, Amengual JE, Mao Y, Nandakumar R, Cremers S, Duong J, Mahadevan D, O'Connor OA. Aurora A Kinase Inhibition Selectively Synergizes With Histone Deactylase Inhibitor Through Cytokinesis Failure In T-Cell Lymphoma. Clin Cancer Res. 2015; 15;21(18):4097-109.

21. Jain S, Jirau-Serrano X, Zullo KM, Scotto L, Palermo CF, Sastra SA, Olive KP, Cremers S, Thomas T, Wei Y, Zhang Y, Bhagat G, Amengual JE, Deng C, Karan C, Realubit R, Bates SE, O'Connor OA. Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma. Clin Cancer Res. 2015;21(9):2096-106.

22. Rubin MR, Goldfine AB, McMahon DJ, Donovan DS, Cremers S, Dworakowski E, Schaefer EJ, Shoelson SE, Silverberg SJ. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus. Endocrine. 2015, In Press.

23. Westhoff CL, Pike MC, Tang R, DiNapoli MN, Sull M, Cremers S. Estimating systemic exposure to ethinyl estradiol from an oral contraceptive. Am J Obstet Gynecol. 2015; 212(5):614.e1-7.

24. Reimers LL, Crew KD, Bradshaw PT, Santella RM, Steck SE, Sirosh I, Terry MB, Hershman DL, Shane E, Cremers S, Dworakowski E, Teitelbaum SL, Neugut AI, Gammon MD. Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk. Cancer Causes Control. 2015 Feb;26(2):187-203.

25. Yoshida K, Jiang H, Kim M, Vink J, Cremers S, Paik D, Wapner R, Mahendroo M, Myers K. Quantitative evaluation of collagen crosslinks and corresponding tensile mechanical properties in mouse cervical tissue during normal pregnancy. PLoS One. 2014;14;9(11):e112391.

26. Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. 2014; 15;5(21):10503-17.

27. Zork NM, Myers KM, Yoshida K, Cremers S, Jiang H, Ananth CV, Wapner RJ, Kitajewski J, Vink J. A systematic evaluation of collagen cross-links in the human cervix. Am J Obstet Gynecol. 2015;212(3):321.e1-8.

28. Claassen J, Albers D, Schmidt JM, Demarchis GM, Pugin D, Falo CM, Mayer SA, Cremers S, Agarwal S, Elkind MS, Connolly ES, Dukic V, Hripcsak G, Badjatia N. Nonconvulsive seizures in subarachnoid hemorrhage link Inflammation and outcome. Ann Neurol. 2014;75(5):771-81.

29. Beasley A, White KO, Cremers S, Westhoff C. Randomized clinical trial of self versus clinical administration of subcutaneous depot medroxyprogesterone acetate. Contraception. 2014;89(5):352-6.

30. Landolt NK, Phanuphak N, Ubolyam S, Pinyakorn S, Kerr S, Ahluwalia J, Thongpaeng P, Thammajaruk N, Cremers S, Thomas T, Chaithongwongwatthana S, Lange JM, Ananworanich J. Significant decrease of ethinylestradiol with nevirapine, and of etonogestrel with efavirenz in HIV-positive women. J Acquir Immune Defic Syndr. 2014;66(2):e50-2.

31. Kalinsky K, Crew KD, Refice S, Xiao T, Wang A, Feldman SM, Taback B, Ahmad A, Cremers S, Hibshoosh H, Maurer M, Hershman DL. Presurgical Trial of Metformin in Overweight and Obese Patients with Newly Diagnosed Breast Cancer. Cancer Invest. 2014;32(4):150-7.

32. Costa AG, Cremers S, Dworakowski E, Lazaretti-Castro M, Bilezikian JP. Comparison of two commercially available ELISAs for circulating sclerostin. Osteoporos Int. 2014;25(5):1547-54.

33. Iyer SP, Nikkel LE, Nishiyama KK, Dworakowski E, Cremers S, Zhang C, McMahon DJ, Boutroy S, Liu XS, Ratner LE, Cohen DJ, Guo XE, Shane E, Nickolas TL. Kidney Transplantation with Early Corticosteroid Withdrawal: Paradoxical Effects at the Central and Peripheral Skeleton. J Am Soc Nephrol. 2014;25(6):1331-41.

34. Yoshida K, Reeves C, Vink J, Kitajewski J, Wapner R, Jiang H, Cremers S, Myers K. Cervical Collagen Network Remodeling in Normal Pregnancy and Disrupted Parturition in Antxr2 Deficient Mice. J Biomech Eng. 2014;136(2):021017.

35. Henrich PP, O'Brien C, Sáenz FE, Cremers S, Kyle DE, Fidock DA. Evidence for Pyronaridine as a Highly Effective Partner Drug for the Treatment of Artemisinin-Resistant Malaria in a Rodent Model. Antimicrob Agents Chemother. 2014;58(1):183-95.

36. Langers P, Press RR, Inderson A, Cremers SC, den Hartigh J, Baranski AG, van Hoek B. Limited Sampling Model for Advanced Mycophenolic Acid Therapeutic Drug Monitoring After Liver Transplantation. Ther Drug Monit. 2014;36(2):141-7.

37. Costa AG, Walker MD, Zhang CA, Cremers S, Dworakowski E, McMahon DJ, Liu G, Bilezikian JP. Circulating Sclerostin Levels and Markers of Bone Turnover in Chinese-American and White Women. J Clin Endocrinol Metab. 2013;98(12):4736-43.

38. Thomas T, Petrie K, Shim J, Abildskov KM, Westhoff CL, Cremers S. A UPLC-MS/MS method for therapeutic drug monitoring of etonogestrel. Ther Drug Monit 2013; 35(6):844-8.

39. Cusano NE, Maalouf NM, Wang PY, Zhang C, Cremers SC, Haney EM, Bauer DC, Orwoll ES, Bilezikian JP. Normocalcemic hyperparathyroidism and hypoparathyroidism in two community-based non-referral populations. J Clin Endocrinol Metab 2013;98(7):2734-41.

40. Cohen A, Stein EM, Recke