About Magnetic Resonance Imaging

Application: Anatomical Imaging

The BioSpec high-field magnetic resonance imager allows for images of your research of the highest caliber possible. Extremely low voxel size and high detail allow for crystal clear imaging of the organs of interest for your research needs. Whether it’s looking for sites of cancer growth in the abdomen, to glioblastoma growth, the MRI allows for consequence free longitudinal imaging throughout your studies. T1 and T2 weighted images allow for multiple methods of high quality morphological imaging and contrast to help identify your regions of interest.

Application: Cardiac Imaging

Dedicated phased-array coils allow for high sensitivity for cardiac imaging of rodents. Accelerated acquisition allows high temporal resolution applications such as first pass myocardial perfusion. Self-gating methods or real-time physiological triggering enables free breathing functional cardiac investigations on your research animals here at Columbia University.

Application: Angiography

The Bruker BioSpec 9.4 tesla MR has the ability to provide high-resolution images of the blood system within the animals of your research. Magnetic Resonance Angiography (MRA) can find problems within the vasculature of the animal that may be causing issues in blood flow and vessel wall condition. Research into aneurysms, and stenosis of blood vessels are common uses for this imaging type.

Application: Perfusion/Diffusion Weighted Imaging

The contrast in Diffusion Weighted Imaging (DWI) originates from the difference in amount of diffusion. Regions that have pathologically disturbed diffusion, such as found when multiple sclerosis, epilepsy, and schizophrenia, stroke, or tumors are present, are easily visible. Greatest sensitivity is achieved with higher b values, which can only be realized with extremely strong gradients. The Bruker BioSpec 9.4 Tesla high-field magnet allows Columbia University Researchers to obtain critical information about:

  • Tumor Infiltration
  • Cardiac Infarction
  • Connectivity
  • Stroke

 

Application: MR Spectroscopy

 

  • The brain, liver, and muscles contain more than just water, and MR spectroscopy makes non-invasive studies of metabolic processes in these tissues possible.
  • Identify metabolic disorders and observe long term changes in metabolic processes even in millimolar concentrations.
  • Higher sensitivity and spectral resolution make this the ideal instrument for spectroscopy and spectroscopic imaging of species involving MR-visible nuclei such as 1H, 13C, 19F, 23Na, 31P and others.

 

Application: fMRI

Functional MR Imaging requires very high magnet and gradient performance in combination with maximum system stability. The Bruker BioSpec Gradient System allows researchers to collect whole brain image data sets in a single take. Excellent shim performance delivers minimum geometrical Mouse Abdomen distortions even when using echo planar imaging techniques. Unique frequency and phase stability enables even segmented diffusion tensor imaging with EPI.

  • Functional neuroimaging procedure
  • Measures Brain Activity
  • Shows active fibers of the brain, or what has been hindered

Please feel free to contact Yanping Sun for any questions or needs for our MRI facility at ys2785@cumc.columbia.edu