Researcher’s Profile

Diane Hamele-Bena, MD


--Academic cytopathologist and breast pathologist with interest in innovative methods of teaching.--

Dr. Hamele-Bena is an award-winning and innovative educator, skilled diagnostician, experienced administrator, and graphic artist. She had the honor to train under mentors of world renown, including Paul Peter Rosen, MD and Leopold G. Koss, MD, throughout the early years of her career in breast pathology, surgical pathology, and cytopathology, and she continues to value being a lifelong mentee as well as a dedicated mentor to the classes of future medical professionals who are being educated at Columbia.

She served for a decade as the Director of the Division of Cytopathology at Columbia, during which time she brought increased process efficiency and academic rigor to the Division and built and developed an outstanding allied medical team.

Dr. Hamele-Bena is prolific in her academic publications, but is equally proud of illustrating and co-authoring a children's book that conveys a positive message to children about embracing diversity and being confident in one's self. She brings this mix of creativity and technical acumen to her teaching, embodied in her "whole-brain" learning approaches and being an early adopter of gamification to reinforce learning comprehension.

She has spoken at multiple external venues both within the US and internationally, and was honored to serve as the only pathologist to join a U.S. medical contingent that traveled to Poland for collaboration and teaching at a week-long multidisciplinary symposium, “Breast Cancer Awareness Program for Poland, at the invitation of the wife of the Polish Ambassador to the United States.



Chen XW, Arend R, Hamele-Bena D, Tergas AI, Hawver M,  Tong GX, Wright TC, Wright JD. Uterine carcinosarcomas: clinical, histopathological, and immunohistochemical characteristics. International Journal of Gynecological Pathology. Accepted for publication in 2017.  

Tong GX, Broadway K, Chang Q, Kong F, Hamele-Bena D. Metastatic insular thyroid carcinoma masquerades as neuroendocrine tumor in lung on CT-guided fine needle aspiration biopsy. Diagnostic Cytopathology. October 2016 44(10):857-859. 

Chen X, Wright JD, Abellar RG, Koehne de Gonzalez A, Collins N, Wright TC, Hamele-Bena D. Cytological features of choriocarcinoma in a Pap smear: A case report and literature review. Diagnostic Cytopathology. April 2016 44(4):324-8. 

Tong GX, Hamele-Bena D. Targeted Next-Generation Sequencing Analysis of a Pendred Syndrome-Associated Thyroid Carcinoma. Endocrine Pathology. March 2016 27(1):70-5. 

Tong GX,  Hawver M, Wei JJ, Chen XW, Hamele-Bena D. Mutually Exclusive Expression of PAX8 and p63 in Transitional Cell Tumors of the Ovary: the Diagnostic and Histogenetic Significance. Journal of Pathology and Microbiology. February 2016 1(1):1-6. 

Green DA, Whittier S, Greendyke W, Win C, Chen X, Hamele-Bena D. Outbreak of Rapidly Growing Nontuberculous Mycobacteria (RG-NTM) Among Patients Undergoing Cosmetic Surgery in the Dominican Republic. Annals of Plastic Surgery. January 2016 78(1):17-21. 

Tong GX, Mody K, Wang Z, Hamele-Bena D, Nikiforova MN, Nikiforov YE. Mutations of TSHR and TP53 Genes in an Aggressive Clear Cell Follicular Carcinoma of the Thyroid. Endocrine Pathology. December 2015 26(4):315-9. 

Wei XJ, Khader S, Hamele-Bena D. Senior author of Cytopathology Chapter in: Anatomic Pathology Board Review, Second Edition. Lefkowitch J, ed. Elsevier, Edinburgh, UK, 2014. 

Chen X, Lagana, S, Poneros, J, Kato, T, Remotti, F, He, H, Kaminsky, D, Hamele-Bena, D.  Cytologic diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation. Diagnostic Cytopathology.  October 2014 42(10):884-889. 

Chen X, Hamele-Bena D, Galic V, Ko YC, Liu-Jarin X, Herzog T, Wright JD, Wright TC. Infiltrating adenomyosis of the cervix with features of a low grade stromal sarcoma: a case report and literature review. International Journal of Gynecologic Pathology. May 2014 33(3):253-7.  

Tong GX, Devaraj K, Hamele-Bena D. Abundant amyloid deposits in endoscopic ultrasound-guided fine needle aspiration biopsy of pancreatic endocrine neoplasms. Diagnostic Cytopathology. December 2013 41(12):1115-7. 
Chen X, Hamele-Bena D, Fai Chow K, Hawver M, He H, Raphael B, Jain S, Wright TC. B-cell lymphoma of the vagina occurring after treatment for classic Hodgkin lymphoma: A case report and literature review. Diagnostic Cytopathology. May 2013 41(5):463-5. 

Tong GX, Hamele-Bena. The differential expression of PAX2 and PAX8 in the ovarian surface epithelium and fallopian tubal epithelium is an important issue. American Journal of Surgical Pathology. July 2012 36(7):1099-100. 

Tong GX, Memeo L, Colarossi C, Hamele-Bena D, Magi-Galluzzi C, Zhou M, Lagana SM, Harik L, Oliver-Krasinski JM, Mansukhani M, Falcone L, Hibshoosh H, O’Toole K. PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract. American Journal of Surgical Pathology. October 2011 35(10):1473-1483. 

Tong GX, Devaraj K, Hamele-Bena D, Yu WM, Turk A, Chen X, Wright JD, Greenebaum E. PAX 8: A marker for carcinoma of Mullerian origin in serous effusions. Diagnostic Cytopathology. August 2011 39(8): 567-574. 

Chen X, Remotti F, Tong GX, Gorczyca E, Hamele-Bena D. Fine needle aspiration cytology of subcutaneous toxoplasmosis: A case report. Diagnostic Cytopathology. October 2010 38(10):716-720. 

Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D. Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagnostic Cytopathology. March 2010 38(3):184-187. 

Tong GX, Yu WM, Beaubier NT, Weeden EM, Hamele-Bena D, Mansukhani MM, O’Toole KM. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Modern Pathology. September 2009 22(9):1218-1227. 

Tong GX, Weeden EM, Hamele-Bena D, Huan Y, Unger P, Memeo L, O’Toole, K. Expression of PAX8 in nephrogenic adenoma and clear cell adenocarcinoma of the lower urinary tract: evidence of related histogenesis? American Journal of Surgical Pathology. September 2008 32(9):1380-1387. 

Tong GX, Hamele-Bena D, Liu JC, Horst B, Remotti F. Fine Needle Aspiration Biopsy of Primary Osteosarcoma of the Thyroid: Report of a Case and Review of the Literature. Diagnostic Cytopathology. August 2008 36(8):589-594. 

Herlitz IK, Tong GX, Hamele-Bena D, Greenebaum E. Nephrogenic ade