Keith R. Brenner, MD
Dr. Brenner graduated from the Johns Hopkins School of Medicine and performed postgraduate training at Columbia University Medical Center, completing residency in internal medicine and fellowship in pulmonary and critical care medicine.
Dr. Brenner’s focus is on providing excellent care to patients with pulmonary disease in the office and hospital setting. His clinical interests include interventional bronchoscopy, lung cancer screening, COPD, asthma, and interstitial lung disease. He participates in research studies of COPD treatment, bronchoscopic lung volume reduction for emphysema, and novel applications of extracorporeal membrane oxygenation (ECMO) as a treatment for respiratory failure.
Dr. Brenner's focus is on providing excellent care to patients with pulmonary disease in the office and hospital setting. He is trained in advanced procedures to diagnose malignant and non-malignant chest conditions and to treat specific complications of advanced thoracic cancers. His research interest is in the use of extracorporeal membrane oxygenation (ECMO) as a treatment for severe respiratory failure and the new application of this technology to patients with COPD.
Brenner K, Cunningham J, Bacchetta M, Brodie D. Catheter Associated Deep Vein Thrombosis And Level Of Anticoagulation In Adult Patients Requiring Extracorporeal Membrane Oxygenation For Respiratory Failure. American Thoracic Society. May 2012. Abstract 27987.
Brenner K, Baldwin MR, Agerstrand CL, Burkart KM, Bulman WA, Bacchetta MD, Brodie D. Improvements in dynamic pulmonary compliance with a very low tidal volume ventilation strategy and extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Am J Respir Crit Care Med 183; 2011:A1648.
Baldwin MR, Bacchetta M, Brodie HD, Brenner K, Agerstrand C.L., Burkart K.M., Bulman W.A., Veno-venous extra corporeal membrane oxygenation with bi-caval dual lumen internal jugular catheter permits safe transport of adult patients with severe acute respiratory distress syndrome. Am J Respir Crit Care Med 183; 2011:A1649.
Agerstrand CA, Baldwin MR, Brodie HD Brenner K, Agerstrand C.L., Burkart K.M., Bulman W.A. Conservative blood transfusion strategies are effective for the management of adult patients with severe acute respiratory distress syndrome requiring extracorporeal membrane oxygenation. Am J Respir Crit Care Med 183; 2011:A1655.
Brenner K, Yip C, Cole S. A 25 year old pregnant woman with a large lung mass. Am J Respir Crit Care Med 181; 2010:A6873.
Keating CL, Wang S, Brenner K, Wang T, Powell C, Circulating Progenitor Cells in Non-Small Cell Lung Cancer Patients. American Thoracic Society. May 2008. Abstract 542.
Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O. Small-molecule inhibitors of HIF-2a translation links its 5’UTR ironresponsive element to oxygen sensing. Molecular Cell. 2008. 32: 838-48.
Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, Konishi Y, Blair BG, Brenner K, Garrett-Mayer E, Carraway H, Bachman KE, Park BH. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proceeding of the National Academy of Science. 2008. 105: 288-93.
Huang Y, Keen JC, Pledgie A, Marton LJ, Zhu T, Sukumar S, Park BH, Blair B, Brenner K, Casero RA Jr, Davidson NE. Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. Journal of Biological Chemistry. 2006. 281:19055-63.
Abukhdeir AM, Blair BG, Brenner K, Karakas B, Konishi H, Lim J, Sahasranaman V, Huang Y, Keen J, Davidson N, Vitolo MI, Bachman KE, Park BH. Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells. Breast Cancer Research and Treatment. 2005. 99:23-33.