Researcher’s Profile

Tamas A. Gonda, MD

Research Statement: 

Dr. Gonda's primary research focus is the study of epigenetic alterations in gastric, esophageal and pancreatic cancer. Epigenetics is the study of genetic changes that result in modification of gene expression by mechanisms other then DNA sequence changes. These changes are early in carcinogenesis and therefore are very attractive markers of disease progression and targets of therapy or prevention. Prior to his faculty appointment, Dr Gonda completed an advanced fellowship in Therapeutic Endoscopy at Columbia University. His clinical research interests and practice are focused on the endoscopic diagnosis and treatment of esophageal and pancreato-biliary malignancies and pancreatitis.

Publications: 

Gonda TA,Varro A,Wang TC,Tycko B.Epigenetic changes in cancer associated fibroblasts.Sem Cell and Dev Biology 2010 Feb;21(1):2-10

Gonda TA,Tu S,Wang TC.Chronic Inflammation,tumor microenvironment and carcinogenesis.Cell Cycle 2009 Jul 1;8(13):2005-13.

Gonda TA,Khan SUZ,Cheng J ,Lewis SK,Rubin M,Green PHR.Intussusception and Celiac Disease.Digestive Dis.Sci.(in press)

Jiang L and Gonda TA.Gamble MV,Salas M,Seshan V,Tu S,Twaddell WS,Hegyi P,Lazar G,Steele I,Varro A,Wang TC,Tycko B.Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts.(Cancer Res.2008 Dec 1;68(23):9900-8.) (Co- first author)

Papavasiliou AK,Magnadottir H,Gonda T,Franz D,Harbaugh RE.Clinical outcomes after carotid endarterectomy: comparison of the use of regional and general anesthetics.Journal of Neurosurgery.2000;92:921-926