Gestational Trophoblastic Disease: Risk Factors

Most molar pregnancies are benign, but some can become malignant.  The following are some risk factors that increase the chance of developing GTD, including signs during pregnancy that you should discuss with your doctor:

  • Pregnancy before age 20 or after age 35
  • Asian, American Indian, and African ancestry
  • History of prior molar pregnancies
  • History of infertility or prior miscarriages
  • Very high level of pregnancy hormone called beta-human chorionic gonadotropin (b-hCG)
  • Large tumor in the uterus
  • Large ovarian cysts during early pregnancy
  • High blood pressure during early pregnancy
  • Hyperactive thyroid gland during pregnancy
  • Severe nausea and vomiting during pregnancy
  • Serious blood clotting problems during pregnancy