Katherine D. Crew, MD
Katherine D. Crew, M.D., M.S. is an Associate Professor of Medicine and Epidemiology at the NewYork-Presbyterian/Columbia University Medical Center. Dr. Crew cares for patients with breast cancer and women at high-risk for breast cancer.
Dr. Crew received her undergraduate B.S. in Biochemistry from Brown University, where she graduated Magna Cum Laude. She received her M.D. from Columbia University College of Physicians and Surgeons and her M.S. from Columbia University School of Public Health. She completed her Internal Medicine residency and Medical Oncology fellowship at NewYork-Presbyterian/Columbia University Medical Center. Dr. Crew is currently involved in patient care, clinical research, and teaching on the Breast Oncology service.
Dr. Crew’s research involves the development of early phase clinical trials for evaluating chemopreventive agents for breast cancer. These studies implement intermediate markers for breast cancer risk, such as mammographic density, tissue- and serum-based biomarkers. In a presurgical study design, women with newly diagnosed breast cancer are given a short-term drug administration during the interval between breast biopsy and surgical resection to test the biologic activity of the drug in breast tumor tissue. In the phase I/II setting, clinical trials are underway to study high-dose vitamin D and a green tea extract, Polyphenon E, in high-risk women.
Dr. Crew also participates in multicenter breast cancer chemoprevention trials through the Phase I/II Chemoprevention Trials Consortium and the Southwest Oncology Group (SWOG). The overall goal of this research is to build a comprehensive, interdisciplinary breast cancer prevention program, which will offer preventive strategies to breast cancer patients and healthy, high-risk women.
Dr. Crew is actively studying how to better identify women at high-risk for breast cancer in the primary care setting using patient-centered decision aids and provider-centered decision support tools embedded within the electronic health record. The overall goal of this work is to adopt risk-appropriate breast cancer screening and prevention strategies.
Peer-Reviewed Research Publications:
Khankari NK, Bradshaw PT, Steck SE, He K, Olshan AF, Ahn J, Terry MB, Crew KD, Teitelbaum SL, Neugut AI, Santella RM, Gammon MD (2017). Interaction between polyunsaturated fatty acids and genetic variants in relation to breast cancer incidence. Journal of Cancer Epidemiology and Prevention (in press).
Ackerman MG, Shapiro PA, Coe A, Trivedi MS, Crew KD (2017). The impact of mental illness on uptake of genetic counseling for hereditary breast and ovarian cancer in a multiethnic cohort of breast cancer patients. Breast Journal (in press).
Cubasch H, Ruff P, Joffe M, Norris S, Chirwa T, Nietz S, Sharma V, Duarte R, Buccimazza I, David R, Shas C, Stopforth LW, Tsai W-Y, Stavsky E, Crew KD, Jacobson JS, Neugut AI (2017). The South African breast cancer and HIV outcomes (SABCHO) study: A multi-center cohort study of HIV and breast cancer in sub-Saharan Africa. Journal of Global Oncology (in press).
Potkul RK, Unger JM, Livingston RB, Crew KD, Wilczynski SP, Salomon CG, Smith BL, Wong L, Campbell DL, Vogel SJ, Anderson GL, Hershman DL, Goodman GE, Brown PH, Meyskens FL, Albain KS (2017). Randomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology with tamoxifen for breast cancer treatment: SWOG S9630. Nature Breast (in press).
Lim EA, Gunther JE, Kim HK, Flexman M, Hibshoosh H, Crew KD, Taback B, Campbell J, Kalinsky K, Hielscher A, Hershman DL (2017). Diffuse optical tomography changes correlate with residual cancer burden after neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Research and Treatment [Epub ahead of print].
Kalinsky K, Zheng T, Hibshoosh H, Du X, Mundi P, Yang J, Refice S, Feldman SM, Taback B, Connolly E, Crew KD, Maurer M, Hershman DL (2017). Proteomic modulation in breast tumors after metformin exposure: Results from a “window of opportunity” trial. Clinical and Translational Oncology, 19:180-188.
Aycinena AC, Valdovinos C, Crew KD, Tsai WY, Mata JM, Sandoval R, Hershman DL, Greenlee H (2017). Barriers to recruitment and adherence in a randomized controlled diet and exercise weight loss intervention among minority breast cancer survivors. Journal of Immigrant and Minority Health, 19:120-129.
Coe AM, Ueng W, Vargas JM, David R, Vanegas A, Infante K, Trivedi M, Yi H, Dimond J, Crew KD, Kukafka R (2016). Usability testing of a web-based decision aid for breast cancer risk assessment among multi-ethnic women. American Medical Informatics Association Annual Symposium Proceedings (in press).
Tang E, Trivedi MS, Kukafka R, Chung WK, David R, Respler L, Leifer S, Schechter I, Crew KD (2016). Population-based study of attitudes toward BRCA genetic testing among Orthodox Jewish women. Breast Journal [Epub ahead of print].
Greenlee H, Gaffney AO, Aycinena AC, Koch P, Contento I, Karmally W, Richardson JM, Shi Z, Lim E, Tsai W-Y, Santella RM, Blaner WS, Clugston RD, Cremers S, Pollak S, Sirosh I, Crew KD, Maurer M, Kalinsky K, Hershman DL (2016). Long-term diet and biomarker changes after a short-term intervention among Hispanic breast cancer survivors: the ¡Cocinar Para Su Salud! Randomized controlled trial. Cancer Epidemiology, Biomarkers and Prevention, 25:1491-1502.
Greenlee H, Sardo Molmenti C, Crew KD, Awad D, Kalinsky K, Brafman L, Fuentes D, Shi Z, Tsai WY, Neugut AI, Hershman DL (2016). Survivorship care plans and adherence to lifestyle recommendations among breast cancer survivors. Journal of Cancer Survivorship, 10:956-963.
Greenlee H, Crew KD, Capodice J, Awad A, Buono D, Shi Z, Jeffres A, Wyse S, Whitman W, Trivedi M, Kalinsky K, Hershman DL (2016). Randomized sham controlled pilot trial of weekly electro-acupuncture for the prevention of taxane-induced peripheral neuropathy in women with early stage breast cancer. Breast Cancer Research and Treatment, 156:453-464.
Yi H, Xiao T, Thomas PS, Aguirre AN, Smalletz C, Dimond J, Finkelstein J, Infanted K, Trivedi M, David R, Vargas J, Crew KD, Kukafka R (2015). Developing decision support tools for breast cancer risk communication for patients and primary care providers. American Medical Informatics Association Annual Symposium Proceedings, 2015:1352-1360. [PMCID: PMC4765687]
Crew KD, Ho KA, Brown P, Greenlee H, Bevers TB, Arun B, Sneige N, Hudis C, McArthur HL, Chang J, Rimawi M, Cornelison TL, Cardelli J, Santella RM, Wang A, Lippman SM, Hershman DL (2015). Effects of an oral green tea extract, Polyphenon E, on systemic biomarkers of growth factor signaling in women with a history of hormone receptor-negative breast cancer. Journal of Human Nutrition and Dietetics 28:272-282. [PMCID: PMC4205214]
Ho KA, Cardelli JA, McLarty J, Hershman DL, Maurer M, Kalinsky K, Taback B, Hibshoosh H, Su T, Refice SF, Crew KD (2015). Evaluating tissue biomarker effects of an oral green tea extract, Polyphenon E, using reverse phase protein array in women with operable breast cancer. International Journal of Food Sciences, Nutrition and Dietetics 4:190-196.
Crew KD, Xiao T, Thomas PS, Maurer M, Kalinsky K, Feldman S, Brafman L, Refice S, Kranwinkel G, Hershman DL (2015). Safety, feasibility, and biomarker effects of vitamin D supplementation among women at high-risk for breast cancer. International Journal of Food Sciences, Nutrition and Dietetics S1:001 1-9.
Chen EI, Crew KD, Trivedi M, Awad D, Maurer M, Kalinsky K, Koller A, Patel P, Kim J, Hershman DL (2015). Identifying predictors of taxane-induced peripheral neuropathy using mass spectrometry-based proteomics technology. PLoS One, 10:e0145816. [PMCID: PMC4692419]
Kukafka R, Yi H, Xiao T, Thomas PS, Aguirre AN, Smalletz C, David R, Crew KD (2015). Why breast cancer risk by the numbers is not enough: Evaluation of a decision aid in multi-ethnic low-numerate women. Journal of Medical Internet Research 17:e165. [PMCID: PMC4526996]
Reimers LL, Sivasubramanian PS, Hershman DL, Terry MB, Greenlee H, Campbell J, Kalinsky K, Maurer M, Jayasena R, Sandoval R, Alvarez M, Crew KD (2015). Breast cancer chemoprevention among high-risk women and those with ductal carcinoma in situ. Breast Journal 21:377-386. [PMCID: PMC4490034]
Greenlee H, Crew KD, Capodice J, Awad D, Jeffres A, Unger JM, Lew D, Hansen L, Hershman DL (2015). Methods to standardize a multicenter acupuncture trial protocol to reduce aromatase inhibitor-related joint symptoms in breast cancer patients. Journal of Acupuncture and Meridian Studies 8:152-158. [PMCID: PMC4705910]
Greenlee H, Gaffney AO, Aycinena AC, Koch P, Contento I, Karmally W, Richardson J, Tsai WY, Crew KD, Maurer M, Kalinsky K, Hershman D (2015). Cocinar Para Su Salud!: Randomized controlled trial of a culturally-based dietary intervention among Hispanic breast cancer survivors. Journal of the Academy of Nutrition and Dietetics 115:709-723. [PMCID: PMC4499508]
Reimers LL, Crew KD, Bradshaw PT, Santella RM, Steck SE, Sirosh I, Terry MB, Hershman DL, Shane E, Cremers S, Dworakowski E, Teitelbaum SL, Neugut AI, Gammon MD (2015). Vitamin D-related genes, plasma 25-hydroxyvitamin D, and breast cancer risk. Cancer Causes Control, 26:187-203. [PMCID: PMC4302042]
McCullough LE, Eng SM, Bradshaw PT, Cleveland RJ, Steck SE, Terry MB, Shen J, Crew KD, Rossner P, Ahn J, Ambrosone CB, Teitelbaum SL, Neugut AI, Santella RM, Gammon MD (2015). Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer. Annals of Epidemiology, 25:263-269. [PMCID: PMC4369423]
Delgado-Cruzata L, Zhang W, McDonald JA, Tsai WY, Valdovinos C, Falci L, Wang Q, Crew KD, Santella RM, Hershman DL, Greenlee H (2015). Dietary modifications, weight loss and changes in metabolic markers effect global DNA methylation in Hispanic, African American and Afro-Caribbean breast cancer survivors. Journal of Nutrition, 145:783-790. [PMCID: PMC4381766]
Hershman DL, Unger JM, Crew KD, Awad D, Dakhil SR, Gralow J, Greenlee H, Lew DL, Minasian LM, Till C, Wade JL, Meyskens FL, Moinpour CM (2015). Randomized multicenter placebo-controlled trial of omega-3-fatty acids for the control of aromatase inhibitor-induced musculoskeletal pain (S0927). Journal of Clinical Oncology 33:1910-1917. [PMCID: PMC4451174]
Crew KD, Campbell J, Reynolds D, Fulton L, Flom J, Liao Y, Tehranifar P, Terry MB (2014). Mammographic density and serum 25-hydroxyvitamin D levels. Nutrition and Metabolism 11:18. [PMCID: PMC3996501]
Work ME, Reimers LL, Quante AS, Crew KD, Whiffen A, Terry MB (2014). Changes in mammographic density over time in breast cancer cases and women at high risk for breast cancer. International Journal of Cancer 135:1740-1744. [PMCID: PMC4107003]
McCullough LE, Santella RM, Cleveland RJ, Millikan RC, Olshan AF, North KE, Bradshaw PT, Eng SM, Terry MB, Shen J, Crew KD, Rossner P, Teitelbaum SL, Neugut AI, Gammon MD (2014). Polymorphisms in DNA repair genes, recreational physical activity, and breast cancer risk. International Journal of Cancer 134:654-663. [PMCID: PMC3830595]
Khankari NK, Bradshaw PT, McCullough LE, Teitelbaum SL, Steck SE, Fink BN, Xu X, Ahn J, Ambrosone CB, Crew KD, Terry MB, Neugut AI, Chen J, Santella RM, Gammon MD (2014). Genetic variation in multiple biologic pathways, flavonoid intake, and breast cancer. Cancer Causes Control 25:215-226. [PMCID: PMC3932534]
Kalinsky K, Crew KD, Maurer M, Refice S, Brafman L, Alvarez M, Sandoval R, Hershman DL (2014). Pre-surgical trial of metformin in overweight and obese patients with newly diagnosed breast cancer. Cancer Investigations 32:150-157. [PMCID: PMC4435671]
Kalinsky K, Lim EA, Andreopoulou E, Desai AM, Jin Z, Tu Y, Hibshoosh H, Wang A, Greenlee H, Crew KD, Maurer M, Sparano JA, Hershman DL (2014). Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer. Cancer Investigations 32:439-444. [PMCID: PMC4428554]
Greenlee H, Crew KD, Mata J, McKinley PS, Rundle A, Zhang W, Yuyan L, Tsai WY, Hershman DL (2013). A pilot randomized controlled trial of a commercial diet and exercise weight loss intervention in minority breast cancer survivors. Obesity, 21:65-76. [PMCID: PMC4705911]
Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL (2013). Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated jo