Andrew F. Teich, MD
Our research focuses on how synaptic plasticity is impaired in neurodegenerative disease, with an emphasis on Alzheimer's disease. We are interested both in studying mechanisms of synaptic dysfunction as well as in identifying targets for therapeutic intervention. Specific issues we are currently focused on are:
1) I am interested in what beta-amyloid is normally doing in the brains of people without Alzheimer's disease. Beta-amyloid is present at low levels in the brain throughout life, and may have an important role in normal brain physiology. Ironically, there is some evidence that beta-amyloid actually facilitates neuronal connectivity and memory in people when it is present at low (normal) concentrations, and becomes toxic to neurons at higher concentrations. By studying its normal function and how it is regulated, we hope to understand better how it may accumulate in the brains of Alzheimer's patients.
2) We are using computational techniques to analyze genome expression data from neurons of Alzheimer's patients to determine whether there are any transcription factors that are primarily responsible for driving synaptic dysfunction in Alzheimer's disease. Transcription factors identified through this effort will be further studied as possible targets for therapeutic intervention.
Peter Koppensteiner, Fabrizio Trinchese, Mauro Fà, Daniela Puzzo, Walter Gulisano, Shijun Yan, Arthur Poussin, Shumin Liu, Ian Orozco, Elena Dale, Andrew F. Teich, Agostino Palmeri, Ipe Ninan, Stefan Boehm & Ottavio Arancio. Scientific Reports, 2016 Sep 1;6:32553. doi: 10.1038/srep32553.
M. Fá, D. Puzzo, R. Piacentini, A. Staniszewski, H. Zhang, M. A. Baltrons, D. D. Li Puma, I. Chatterjee, J. Li1, F. Saeed, H. L. Berman, C. Ripoli, W. Gulisano, J. Gonzalez, H. Tian, J. A. Costa, P. Lopez, E. Davidowitz, W. H. Yu, V. Haroutunian, L. M. Brown, A. Palmeri, E. M. Sigurdsson, K. E. Duff, A. F. Teich, L. S. Honig, M. Sierks, J. G. Moe, L. D’Adamio, C. Grassi, N. M. Kanaan, P. E. Fraser & O. Arancio. Extracellular Tau Oligomers Produce an Immediate Impairment of LTP and Memory. Scientific Reports, 2016 Jan 20;6:19393.
A. F. Teich, Sakurai M., Patel M., Holman C., Saeed F., Fiorito J., Arancio O. PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease. Journal of Alzheimer’s Disease, 2016 9;52(1): 295-302.
Gill BJ, Pisapia DJ, Malone HR, Goldstein H, Lei L, Sonabend A, Yun J, Samanamud J, Sims JS, Banu M, Dovas A, Teich AF, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Sims PA, Canoll P. MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. (2014)26;111(34):12550-5.
Teich AF, Patel M, Arancio O. A Reliable Way to Detect Endogenous Murine β-Amyloid. PLoSOne. (2013) 8(2):e55647.