Julian Abrams, MD, MPH
Dr. Abrams is a specialist in the care of patients with Barrett's esophagus, early esophageal cancer, and other esophageal disorders. Prior to his faculty appointment here at Columbia, Dr. Abrams received further training in cancer epidemiology through a post-doctoral fellowship as part of the NCI-funded Training Program in Cancer-Related Population Sciences. He previously received a K07 career development award from the National Cancer Institute.
The major areas of Dr. Abrams’ research relate to the epidemiology of Barrett’s esophagus and esophageal cancer, biomarker studies of risk of progression, and prevention of esophageal cancer. Dr. Abrams also works closely with Dr. Charles Lightdale on clinical trials using novel endoscopic techniques for the treatment of dysplasia and early cancer in patients with Barrett’s esophagus. They are also involved in clinical trials of the prevention of esophageal cancer.
Wang JS, Varro A, Lightdale CJ, Letkorwit N, Slack KN, Fingerhood ML, Tsai WY, Wang TC, Abrams JA. Elevated serum gastrin is associated with a history of advanced neoplasia in patients with Barrett’s esophagus. Am J Gastroenterol 2010;105:1039-45. PMC3139948
Quante M, Bhagat G, Abrams JA, Marache F, Good P, Lee MD, Lee Y, Friedman R, Mahmood U, Figueireido J, Lightdale CJ, Rustgi AK, Wang TC. Bile acids and inflammation activate gastric cardia stem cells in a model of Barrett’s-like metaplasia. Cancer Cell 2012;21:36-51. PMC3266546
Abrams JA, Beer DG, Berry L, Chak A, Falk GW, Fitzgerald R, Grady W, Lynch JP, Rustgi AK, Richmond E, Seibel EJ, Shyr Y, Umar A, Wang KK, Wang TC, Wang TD, Yassin R. Barrett's Esophagus Translational Research Network (BETRNet): The pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research. Gastroenterology 2014;146(7):1586-90. PMC4224108
Lee Y, Urbanska A,Wang H, Hayakawa Y, Jin G, Bhagat G, Abrams JA, Friedman RA, Varro A, Wang KK, Rustgi AK, Quante M, Wang TC. CCK2R marks a gastrin-responsive stem cell in the cardia that gives rise to Barrett’s esophagus in a mouse model. Oncotarget 2016 Jul 18. doi: 10.18632/oncotarget.10667. [Epub ahead of print] PMID: 27448962 (PMCID pending)
Abrams JA, Kapel RC, Lindberg GM, Saboorian MH, Genta RM, Neugut AI, Lightdale CJ. Adherence to biopsy guidelines for Barrett’s esophagus surveillance in the community setting in the United States. Clin Gastroenterol Hepatol 2009;7:736-42. PMC3139243
Abrams JA, Sharaiha RZ, Gonsalves L, Lightdale CJ, Neugut AI. Dating the rise of esophageal adenocarcinoma: Analysis of Connecticut Tumor Registry Data, 1940-2007. Cancer Epidemiol Biomarkers Prev 2011;20:183-86. PMC3018857
Gupta M, Lutzke L, Gorospe EC, Iyer PG, Abrams JA, Falk GW, Ginsberg GG, Rustgi AK, Lightdale CJ, Wang TC, Fudman DI, Poneros JM, Schleck CD, Zinsmeister AR, Wang KK. Recurrence of Esophageal Intestinal Metaplasia after Endoscopic Mucosal Resection and Radiofrequency Ablation of Barrett's Esophagus: Results from a U.S. Multicenter Consortium. Gastroenterology 2013;145:79-86. PMC3696438
Fudman DI, Lightdale CJ, Poneros JM, Ginsberg GG, Falk GW, Demarshall M, Gupta M, Iyer PG, Lutzke L, Wang KK, Abrams JA*. Positive correlation between endoscopist radiofrequency ablation volume and response rates in Barrett’s esophagus. Gastrointest Endosc 2014;80:71-7. PMC4317349
Sharaiha RZ, Halazun KJ, Mirza F, Port JL, Lee PC, Neugut AI, Altorki NK, Abrams JA. Elevated preoperative neutrophil:lymphocyte ratio as a predictor of post-operative disease recurrence in esophageal cancer. Ann Surg Oncol 2011;18:3362-69. PMC3192937
Araujo J, Altorki N, Sonett J, Rodriguez A, Sungur-Stasik K, Neugut AI, Abrams JA. Pre-diagnosis aspirin use and outcomes in a prospective cohort of esophageal cancer patients. Therap Adv Gastroenterol 2016;9:806-814. PMC5076766.
Freedberg DE, Lebwohl B, Abrams JA. The impact of proton pump inhibitors on the human gastrointestinal microbiome. Clin Lab Res 2014;34:771-785. PMC4254461
Freedberg DE, Lamouse-Smith ES, Lightdale JR, Jin Z, Yao YX, Abrams JA. Use of acid suppression medication is associated with risk for C. difficile infection in infants and children: A population-based study. Clin Infect Dis 2015;61:912-17. PMC4551005
Freedberg DE, Toussaint NC, Chen SP, Ratner AJ, Whittier S, Wang TC, Wang HH, Abrams JA. Proton Pump Inhibitors Alter Specific Taxa in the Human Fecal Microbiome: Results of a Crossover Trial. Gastroenterology 2015;149:883-885. PMC4584196
Jackson MA, Goodrich JK, Maxan ME, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ. Proton pump inhibitors alter the composition of the gut microbiota. Gut. 2016 May;65(5):749-56. PMC4853574.
Snider EJ, Freedberg DE, Abrams JA. Potential Role of the Microbiome in Barrett's Esophagus and Esophageal Adenocarcinoma. Dig Dis Sci. 2016 Apr 11. [Epub ahead of print] PMID: 27068172. (PMCID pending, NIHMS ID 777191)