Multiple Myeloma: Symptoms

As myeloma cells increase, the bones begin to degenerate, releasing calcium into the bloodstream. This condition, known as hypercalcemia, can affect the heart, kidneys, gastrointestinal tract and brain but it is often reversible if caught early enough. The symptoms of hypercalcemia include:

• Constipation
• Fatigue
• Frequent urination
• Frequent thirst
• Muscle weakness
• Drowsiness or confusion

Other symptoms related to MM are

• Bone pain
• Weight loss
• Repeated infections
• Weakness or numbness in the legs
• Back pain
• Rib pain
• Broken bones, usually in the spine

Some people with MM may not have any symptoms. In these cases, myeloma protein is found in the blood or urine when tests are done for other purposes.