Researcher’s Profile

Michael M. Shen, PhD

Department of Medicine
Division of Hematology/Oncology
Department of Genetics & Development
Director of Graduate Studies, Department of Genetics & Development

Molecular mechanisms of pattern formation and cellular differentiation during mouse embryogenesis; Organogenesis and regeneration of the prostate gland; Mouse models of prostate cancer.

1. Wang, X., Kruithof-de Julio, M., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C., and Shen, M. M.: (2009) A luminal epithelial stem cell that is a cell of origin for prostate cancer.  Nature  461: 495-500. 2. Shen, M. M., and Abate-Shen, C. (2010). Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 24: 1967-2000.  3. Kruithof-de Julio, M., Alvarez, M. J., Galli, A., Chu, J., Price, S. M., Califano, A., and Shen, M. M.: (2011) Regulation of extraembryonic endoderm stem cell differentiation by Nodal and Cripto signaling.  Development  138: 3885-3895  4. Wang, Z. A., Mitrofanova, A., Bergren, S. K., Abate-Shen, C., Cardiff, R. D., Califano, A., and Shen, M. M.: (2013) Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity.  Nat. Cell Biol.  15: 274-283  5. Wang, Z. A., Toivanen, R., Bergren, S. K., Chambon, P., and Shen, M. M.: (2014) Luminal cells are favored as the cell of origin for prostate cancer.  Cell Rep.  8: 1339-1346  6. Chua, C. W., Shibata, M., Lei, M., Toivanen, R., Barlow, L. J., Bergren, S. K., Badani, K. K., McKiernan, J. M., Benson, M. C., Hibshoosh, H., and Shen, M. M.: (2014) Single luminal epithelial progenitors can generate prostate organoids in culture.  Nat. Cell Biol.  16: 951-961  7. Toivanen, R., Mohan, A., and Shen, M. M. (2016). Basal progenitors contribute to repair of the prostate epithelium following induced luminal anoikis. Stem Cell Rep. 6: 660-667.  8. Toivanen, R., and Shen, M. M. (2017). Prostate organogenesis: tissue induction, hormonal regulation and cell type specification. Development 144, 1382-1398.