Researcher’s Profile

Michael M. Shen, PhD

Department of Medicine
Division of Hematology/Oncology
Department of Genetics & Development
Director of Graduate Studies, Department of Genetics & Development

Molecular mechanisms of pattern formation and cellular differentiation during mouse embryogenesis; Organogenesis and regeneration of the prostate gland; Mouse models of prostate cancer.

1. Wang, X., Kruithof-de Julio, M., Economides, K. D., Walker, D., Yu, H., Halili, M. V., Hu, Y.-P., Price, S. M., Abate-Shen, C., and Shen, M. M.: (2009) A luminal epithelial stem cell that is a cell of origin for prostate cancer.  Nature  461: 495-500. 2. Shen, M. M., and Abate-Shen, C. (2010). Molecular genetics of prostate cancer: new prospects for old challenges. Genes Dev. 24: 1967-2000.  3. Kruithof-de Julio, M., Alvarez, M. J., Galli, A., Chu, J., Price, S. M., Califano, A., and Shen, M. M.: (2011) Regulation of extraembryonic endoderm stem cell differentiation by Nodal and Cripto signaling.  Development  138: 3885-3895  4. Wang, Z. A., Mitrofanova, A., Bergren, S. K., Abate-Shen, C., Cardiff, R. D., Califano, A., and Shen, M. M.: (2013) Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell of origin model for prostate cancer heterogeneity.  Nat. Cell Biol.  15: 274-283