Physician’s Profile

Matthias J. Szabolcs, MD

Department of Pathology & Cell Biology
Division of Anatomic Pathology
Board Certificates
Anatomic Pathology
Areas of Expertise:
  • Surgical Pathology

1. Li Z, Szabolcs M, Terwilliger JD, Efstratiadis A. Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene. Carcinogenesis. 2006 May;27(5):1054-67. PMID: 16401639

2.   Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-tsakonas S, Efstratitdis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006; 103(24):9262-7. PMID: 16751266

3.  Efstratiadis A, Szabolcs M, Klinakis A. Notch, Myc and Breast Cancer. Cell Cycle. 2007 Feb 9;6(4). PMID: 17329972

4.  Shakya R, Szabolcs M, Mc Carthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T. The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci U S A. 2008;105(19):7040-5. PMID: 18443292

5.   Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not on its E3 ligase activity. Science 2011; 334(6055):525-528 PMID:22034435

6.   Reczek CR, Szabolcs M, Stark JM, Ludwig T, Baer R. The interaction between CTIP and BRCA1 is not essential for resection mediated DNA repair of tumor suppression. J Cell Biol. 2013 May 27; 201(5):693-707. PMID: 23712259

7. Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. Am J Pathol. 2009; 174:276-86. PMID: 19095950

8. Klinakis A, Szabolcs M, Chen G, Xuan S, Hibshoosh H, Efstratiadis A. Ifgr1 is a therapeutic target in a mouse model of basal-like breast cancer. Proc Natl Acad Sci U S A. 2009;106:2359-64. PMID: 19174523 

9.   Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A. Therapeutic effect of an anti-myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Oct 11; 106(12). pii: dju320. doi: 10.1093/jnci/dju320. PMID:25306215

10. Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. 2014 Nov 15; 5(21):10503-17. PMID: 25361177

11. Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R. The DNA resection protein CtIP promotes mammary tumorigenesis. Oncotarget. 2016 Apr 6. [Epub ahead of print] PMID:27058754