For women who are at average risk, there are no screening tests for uterine cancer. Sometimes abnormal cells from the uterus and endometrial cancer are detected by Pap smear although the primary reason for undergoing Pap testing is for the detection of cervical cancer.
Women who are at high risk for the development of endometrial cancer sometimes undergo screening tests or prophylactic surgery. The most important risk for endometrial cancer is Lynch syndrome or Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC). Lynch syndrome is a genetic disorder that places women at increased risk for a number of cancers including endometrial cancer and colon cancer.
Women with Lynch syndrome should undergo increased screening for endometrial cancer. Screening typically involves yearly endometrial biopsy beginning at age 35. Women with Lynch syndrome who have completed childbearing may consider prophylactic hysterectomy.