Researcher’s Profile

Denise B. Kandel, PhD

Body: 

Denise Kandel, PhD., Head of the Department of Epidemiology of Substance Abuse at the New York State Psychiatric Institute, Professor of Sociomedical Sciences and Psychiatry at Columbia University. Major interests: the epidemiology, risk factors, and consequences of drug use, in particular smoking; the epidemiology of substance dependence; developmental pathways of problem behaviors in adolescence; the intergenerational transmission of deviance; animal models of epidemiological paradigms.

Current research activities focus on five areas: 1) the epidemiology of adolescent smoking; 2) the Gateway Hypothesis of drug involvement; 3) the intergenerational effects of parental drug use on child drug behavior and development; 4) epidemiology of non-medical prescription drug use; 5) epidemiology of post-traumatic stress disorder.

Research Statement: 

The epidemiology, risk factors, and consequences of drug use, in particular smoking; the epidemiology of substance dependence; developmental pathways of problem behaviors in adolescence; the intergenerational transmission of deviance; animal models of epidemiological paradigms.

Current research activities focus on five areas: 1) the epidemiology of adolescent smoking; 2) the Gateway Hypothesis of drug involvement; 3) the intergenerational effects of parental drug use on child drug behavior and development; 4) epidemiology of non-medical prescription drug use; 5) epidemiology of post-traumatic stress disorder.

Publications: 

Kandel DB: Stages and Pathways of Drug Involement: Examining the Gateway Hypotheis, Cambridge University Press, Cambridge, England, 2002

Hu M-C, Griesler P, Schaffran C, Kandel DB: Risk and Protective Factors for Nicotine Dependence in Adolescence.  J Child Psychol & Psychiatry 2011;52: 1063-1072

Levine A, Huang YY, Disraldi B, Griffin Jr E, Pollak DD, Xu S, Yin D, Schaffran C, Kandel DB, Kandel ER: Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine. Sci Trans Med 2011;3: 107ra109

Koob G, Kandel DB, Baler RD, Volkow N: Pathophysiology of Addiction, John Wiley & Sons, West Sussex,England, 2015

Kandel ER, Kandel DB: Shattuck Lecture: A Basis for Nicotine as a Gateway Drug. NEJM 2014;371: 932-943