Multicenter Expanded Access Protocol of ATA129 forSubjects with Epstein-Barr Virus-Associated Viremia or Malignancies for Whom There are No Appropriate Alternative Therapies

Protocol: 
AAAR0039
Phase: 
II

Multicenter Expanded Access Protocol of ATA129 forSubjects with Epstein-Barr Virus-Associated Viremia or Malignancies for Whom There are No Appropriate Alternative Therapies

Epstein-Barr Virus (EBV) is the virus that causes mononucleosis, also known as “mono”. Almost all adults have had EBV. For most people, EBV never causes a health problem. However, when their immune system is not working properly (people who have had a transplant and those who have immune disorders), EBV can cause certain diseases where cells grow abnormally. Special immune cells, called T cells, have been made that could attack the abnormal cells. If you participate, you will receive special immune cells called EBV-Cytotoxic T Lymphocytes (EBV-CTLs), made in the laboratory starting with cells from a healthy person who is immune to EBV. Treatment for you will be selected for you from a bank of frozen EBV-CTLs, based on sharing certain human leukocyte antigens (HLAs), which the EBV-CTLs need to work. EBV-CTLs have been studied previously in 2 trials. The purpose of this study is to allow you to be treated with EBV-CTLs if you have had a transplant or immune disorder and an EBV disease and there is no other satisfactory treatment options or you do not qualify to take part in other EBV-CTL studies. Your participation will help us to understand about responses to treatment and any side effects that may occur in research subjects/participants treated with EBV-CTLs.

Are you Eligible? (Inclusion Criteria)

1. A diagnosis of EBV+ LPD or lymphoma
2. Availability of appropriate HLA partially-matched and restricted EBV-CTLs
3. No other comparable or satisfactory therapies available for treatment of
EBV+ disease
4. Not eligible for any other trials supporting development of EBV-CTLs

Specialty Area(s)

Trial Location

Herbert Irving Comprehensive Cancer Center
161 Fort Washington Ave.
Herbert Irving Pavilion
New York, NY 10032
United States