Gut Microbiota, Butyrate, Inflammation and Physical Activity: A pilot study among individuals at high risk for colorectal cancer

Protocol: 
AAAP1611
Phase: 
Pilot

Gut Microbiota, Butyrate, Inflammation and Physical Activity: A pilot study among individuals at high risk for colorectal cancer

The primary purpose of this research study is to learn about the effect of physical activity on various microorganisms (often called “gut flora”) that reside in the colon. Our objective is to study this association among people who have had a polyp removed from their colon. There are many risk factors for colorectal cancer, such as genetic and lifestyle behaviors factors. Various microorganisms in the colon have been linked to colorectal cancer by influencing the inflammation process. In addition, it is still unknown whether chances in lifestyle factors, such as exercise, are beneficial to the gut flora.

Are you Eligible? (Inclusion Criteria)

1) history of >1cm adenoma diagnosed within the past 12 months;
2) no history of colon or rectal cancer; 3
3) no use of antibiotics in the previous 3 months;
4) not currently regularly exercising;
5) willing and able to go to a gym 5 days a week for 4 weeks.

Specialty Area(s)

Trial Location

Herbert Irving Comprehensive Cancer Center
161 Fort Washington Ave.
Herbert Irving Pavilion
New York, NY 10032
United States