Researcher’s Profile

Chyuan-Sheng Lin, PhD

Research Statement: 

I am the manager of HICCC Transgenic Mouse Shared Resource (TMSR) managing the production of genetically modified and transgenic mice for Columbia University researchers. I implemented BAC recombineering as a tool to generate gene targeting vectors, and to modifiy BAC for BAC transgenic mouse production. My staff and I started to test CRISPR/Cas genome editing approaches in 2014 and are in the process of optimizing the CRISPR HDR repair in mice. My lab studies genes involved in retinal degeneration. We are particular interested in the point mutations that cause the degeneration of photoreceptors.


Sancho-Pelluz J, Tosi J, Hsu CW, Lee F, Wolpert K, Tabacaru MR, Greenberg JP, Tsang SH, Lin CS. Mice with a D190N mutation in the gene encoding rhodopsin: a model for human autosomal-dominant retinitis pigmentosa. Mol Med. 2012 May 9;18:549-55. PubMed PMID: 22252712; PubMed Central PMCID: PMC3388123. 

Lin CS, Lim SK, D'Agati V, Costantini F. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64. PubMed PMID: 8566749.