Researcher’s Profile

Carrie Shawber

Assistant Professor of Reproductive Sciences in OB/Gyn & Surgery
Body: 

Carrie Shawber is an Assistant Professor of Reproductive Sciences in Obstetric & Gynecology and Surgery. Dr. Shawber received her BS in Biology and PhD in Molecular Biology from University of California, Los Angeles. After completing her graduate studies on Mammalian Notch Signaling, Dr. Shawber trained as a postdoctoral research fellow at Weill Cornell Medical College in Cancer Genetics and Epigenetics and Columbia University in Vascular Biology. Her studies of embryonic lymphatic development and lymphatic anomalies have received funding from the Department of Defense, National Cancer Institute, and National Institute of Biomedical Imaging and Bioengineering, as well as private foundations. Dr. Shawber’s laboratory is currently funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the Million Dollar Bike Ride Grant Program, and the Lipedema Foundation.  

Research Statement: 

The Shawber laboratory is interested in understanding developmental and pathological lymphatic vascular biology. We use conditional genetic mouse models to study the role of Notch, MMPs, and RERE in lymphatic endothelial specification, remodeling, and homeostasis with a focus on the digestive track and the skin. Information gained from our murine genetic studies is used to understand human pathological lymphatic disorders and diseases, such as Down syndrome, Turner syndrome, lymphatic malformations, congenital chylothoraxes, and generalized lymphatic anomalies. In collaboration with Dr. June Wu, a Plastic Surgeon at CUMC, we developed a Basic and Translational Vascular Anomalies Research Program in January 2014 with the goals to characterize and identify the genetic and molecular causes of blood and lymphatic vascular anomalies/disorders/diseases, as well as improve diagnosis via new imaging methodologies and identify optimal treatment options for patients.

Publications: 

Wu, J.K., Hooper, E.D., Laifer-Narin, S.L., Simpson, L.L., Kandel, J.J. and Shawber, C.J. (2016) Initial experience with propranolol treatment of lymphatic anomalies: A Case Series. Pediatrics. 138:e20154545.

Shawber, C.J., Lin, L., Gnarra, M., Sauer, M.V., Papaioannou, V.E., Kitajewski, J.K., and Douglas, N.C. (2016) Peri-implantation vasculature and expression of Notch proteins and ligands in the mouse uterus. Vascular Cell. 7:9.

Wu, J.K., Kitajewski, C., Reiley, M., Andrews, J.P., Thirumoorthi, A., Wong, A., Keung, C.H., Monteagudo, J., Kitajewski, A., Sastra, S., Behr, G., Kandel, J.J.*, and Shawber, C.J.* (2015) Aberrant Lymphatic endothelial progenitor cells in lymphatic malformation development. PLoS One. 10:e0117352. (*Co-senior Authorship)

Kangsamaksin, T., Murtomaki, A., Kofler, N.M., Cuervo, H., Chaudhri, R.A., Tattersall, I.W., Rosenstiel, P.E., Shawber C.J., and Kitajewski, J.  (2015) Notch Decoys that Selectively Block Dll/Notch or Jagged/Notch Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth. Cancer Discovery. 5:182-197.

Douglas, N.C., Zimmermann, R.C., Tan, Q-K., Sullivan-Pyke, C.S., Sauer, M.V., Kitajewski, J.K., and Shawber, C.J. (2014) VEGFR-1 blockade disrupts peri-implantation decidual macrophage recruitment and angiogenesis. Vascular Cell. 6:16.