Physician’s Profile

Akiva Mintz, MD, PhD

Department of Radiology
Division of Nuclear Medicine
Vice Chair of Translational Imaging, Department of Radiology at CUMC
Director, Columbia University PET Center
Division Chief, Nuclear Medicine and Molecular Imaging
Introduction:

Akiva Mintz, M.D., Ph.D, is a physician-scientist whose translational research focuses on developing and personalizing cancer therapies using non-invasive molecular imaging. He obtained his medical and graduate degrees at the Pennsylvania State University College of Medicine where he helped discover and therapeutically exploit a new cancer restricted biomarker in malignant brain cancer. Dr. Mintz subsequently completed a Nuclear Medicine residency and an NIH-sponsored molecular imaging fellowship at the University of Pennsylvania, where he developed novel preclinical multimodality imaging tools to non-invasively visualize disease and early response to therapy. Dr. Mintz is Dual-Board Certified in Nuclear Medicine and Clinical Informatics. In addition to his medical training, Dr. Mintz is a CFA charterholder and completed a Masters in Healthcare Administration (MHA) at the University of North Carolina at Chapel Hill. 

Dr. Mintz is Professor of Radiology at Columbia University Medical Center and Attending Radiologist at New York Presbyterian Hospital. He also is Vice Chairman of Translational Research, Director of the Kreitchman PET Center and Division Chief of the Nuclear Medicine division. Prior to Columbia, Dr. Mintz worked at Wake Forest, where he held a number of leadership roles, including Vice Chair of Radiology and Section Head of Nuclear Medicine. Dr. Mintz was also the Associated Director of the Wake Forest Clinical and Translational Science Institute and Co-leader of the Cancer Biology and Biochemistry Program of the NCI-designated Wake Forest Comprehensive Cancer Center.

Dr. Mintz’s cross-translational research efforts exploit nuclear-based molecular imaging and therapy techniques to personalize anti-cancer therapies. His work is funded by multiple NIH grants and the American Cancer Society. 

Board Certificates
Nuclear Medicine
Clinical Informatics
Publications:

1.    Sattiraju A, Solingapuram Sai KK, Xuan A, Pandya D, Almaguel F, Wadas T, Herpai D, Debinski W,  *Mintz A. IL13RA2 targeted alpha particle therapy against glioblastoma. In Press, Oncotarget (2017).

2.    Prabhakaran J, Zanderigo F, Solingapuram Sai KK, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Mintz A, Mann JJ, Kumar D. Radiosynthesis and In Vivo Evaluation of [11C]A1070722, a High Affinity GSK3 PET Tracer in Primate Brain. In Press, ACS Chemical Neuroscience (2017).

3.    Prazeres P, Sena I, Borges I, Azevedo P, Andreotti J, Paiva A, Almeida V, Guerra DA, Santos G, Mintz A, Delbono O, Birbrair A. Pericytes are heterogeneous in their origin within the same tissue (2017) in press Developmental Biology.

4.    Solingapuram Sai KK, Prabhakaran J, Sattiraju A, Mann JJ, Mintz A, Kumar JSD. Radiosynthesis and evaluation of IGF1R PET ligand [11C]GSK1838705A. In Press Bioorganic & Medicinal Chemistry Letters (2017).

5.    Sun Y, Xiong X, Pandya D, Jung Y, Mintz A*(corresponding), Hayasaka S, Wadas TJ, Li KC. Enhancing tissue permeability with MRI guided preclinical focused ultrasound system in rabbit muscle: from normal tissue to VX2 tumor.  In Press Journal of Controlled Release (2017).

6.    Tyrrell DJ, Bharadwaj MS , Jorgensen, MJ, Register TC, Shively C, Andrews R, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxidative Medicine and Cellular Longevity. In Press (2017).

7.    Gottesman RF, Schneider ALC, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH. Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition. JAMA (2017) 317 (14), 1443-1450.

8.    Solingapuram Sai KK, Sattiraju A, Almaguel FG, Xuan A, Rideout S, Krishnaswamy RS, Zhang J, Herpai DM, Debinski W, *Mintz A. Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker. In Press, Oncotarget (2017).

9.    Solingapuram Sai KK, Das B, Almaguel FG, Sattiraju A, *Mintz A. Radiolabeling and initial biological evaluation of [18F]KBM-1 for imaging RAR-α receptors in neuroblastoma. Bioorganic & Medicinal Chemistry Letters (2017) 27 (6), 1425-1427.

10.  Solingapuram Sai KK, Mintz A. Metabolic PET Imaging. (2017) In Press, American Journal of Roentgenology (AJR).

11.  Sattiraju A, Solingapuram Sai KK, Mintz A. GBM stem cells in the tumor microenvironment. Advances in Experimental Medicine and Biology (Springer). Accepted for Publication (2017).

12.  Wang L, Habib AA, Mintz A, Li KC, Zhao D. Phosphatidylserine-targeted nanotheranostics for brain tumor imaging and therapeutic potential. (2017) In Press, Molecular Imaging.

13.  Solingapuram Sai KK, Gage D, Neth B, Hughes, Tremblay S., Castellano CA, Cunnane S, Jorgenson M, Kaplan J, Craft S. Mintz A*. Automated Synthesis of [11C]acetoacetate on a TRASIS AIO module with non-human primate whole body PET imaging.  Applied Radiation and Isotopes (2016) Accepted for publication.

14.  Hu Y, Feng X, Mintz A, Petty W, Hsu W. Regulation of brachyury by fibroblast growth factor receptor 1 in lung cancer. Oncotarget (2016) 7:87124.

15.  Prabhakaran J, Solingapuram Sai KK, Zanderigo F, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Tooke KI, Mintz A, Mann JJ. Kumar D. In vivo evaluation of [18F]FECIMBI-36, an agonist 5-HT2A/2C receptor PET radioligand in nonhuman primate Bioorganic & Medicinal Chemistry Letters (2016) 27 (1), 21-23

16.  Y Hu, R Singh, Z Deng, A Mintz, W Hsu. Liposome-Protamine-DNA Nanoparticle-Mediated Delivery of Short Hairpin RNA Targeting Brachyury Inhibits Chordoma Cell Growth. Journal of Biomedical Nanotechnology (2016) 12 (10), 1952-1961.

17.  Lodge MA, Holdhoff M, Leal JP, Bag AK, Nabors LB, Mintz A, Lesser GJ, Mankoff DA, Desai AS, Mountz JM, Lieberman FS, Fisher JD, Desideri S, Ye X, Grossma SA, Schiff D, Wahl RL. Repeatability of 18F-FLT PET in a Multi-Center Study of Patients with High Grade Glioma. (2016) Journal of Nuclear Medicne and Moleclar Imaging 58:393-398.

18.  Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi, ML, Solingapuram Sai KK, Marini FC, Delbono O, *Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas (2016) Stem Cells Translational Medicine 5:1-11.

19.  RF Gottesman, ALC Schneider, Y Zhou, X Chen, E Green, N Gupta, DS Knopman, A Mintz, A Rahmim, AR Sharrett, LE Wagenknecht, DF Wong, TH Mosley. The ARIC-PET Amyloid Imaging Study: Brain Amyloid Differences by Age, Race, Sex, and APOE. (2016) Neurology 87 (5), 473-480.